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COVID-19, Neuropathology, and Aging: SARS-CoV-2 Neurological Infection, Mechanism, and Associated Complications.
Kalra, Rajkumar Singh; Dhanjal, Jaspreet Kaur; Meena, Avtar Singh; Kalel, Vishal C; Dahiya, Surya; Singh, Birbal; Dewanjee, Saikat; Kandimalla, Ramesh.
  • Kalra RS; AIST-INDIA DAILAB, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
  • Dhanjal JK; Department of Computational Biology, Indraprastha Institute of Information Technology Delhi, Okhla Industrial Estate, New Delhi, India.
  • Meena AS; CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India.
  • Kalel VC; Department of Systems Biochemistry, Institute of Biochemistry and Pathobiochemistry, Faculty of Medicine, Ruhr-University Bochum, Bochum, Germany.
  • Dahiya S; Conservative Dentistry and Endodontics, Maharishi Markandeshwar College of Dental Sciences and Research, Ambala, India.
  • Singh B; ICAR-Indian Veterinary Research Institute (IVRI), Regional Station, Palampur, India.
  • Dewanjee S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
  • Kandimalla R; Applied Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India.
Front Aging Neurosci ; 13: 662786, 2021.
Article in English | MEDLINE | ID: covidwho-1278422
ABSTRACT
The spectrum of health complications instigated by coronavirus disease 2019 (COVID-19, caused by the novel severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) pandemic has been diverse and complex. Besides the evident pulmonary and cardiovascular threats, accumulating clinical data points to several neurological complications, which are more common in elderly COVID-19 patients. Recent pieces of evidence have marked events of neuro infection and neuroinvasion, producing several neurological complications in COVID-19 patients; however, a systematic understanding of neuro-pathophysiology and manifested neurological complications, more specifically in elderly COVID-19 patients is largely elusive. Since the elderly population gradually develops neurological disorders with aging, COVID-19 inevitably poses a higher risk of neurological manifestations to the aged patients. In this report, we reviewed SARS-CoV-2 infection and its role in neurological manifestations with an emphasis on the elderly population. We reviewed neuropathological events including neuroinfection, neuroinvasion, and their underlying mechanisms affecting neuromuscular, central- and peripheral- nervous systems. We further assessed the imminent neurological challenges in the COVID-19 exposed population, post-SARS-CoV-2-infection. Given the present state of clinical preparedness, the emerging role of AI and machine learning was also discussed concerning COVID-19 diagnostics and its management. Taken together, the present review summarizes neurological outcomes of SARS-CoV-2 infection and associated complications, specifically in elderly patients, and underlines the need for their clinical management in advance.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Systematic review/Meta Analysis Language: English Journal: Front Aging Neurosci Year: 2021 Document Type: Article Affiliation country: Fnagi.2021.662786

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Systematic review/Meta Analysis Language: English Journal: Front Aging Neurosci Year: 2021 Document Type: Article Affiliation country: Fnagi.2021.662786