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Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia.
Alkindi, S; Elsadek, R A; Al-Madhani, A; Al-Musalhi, M; AlKindi, S Y; Al-Khadouri, G; Al Rawahi, B; Al-Ruqeishi, S; Al-Yazeedi, J; Wali, Y A; Al Shamakhi, S; Al Rawahi, M; Pathare, A V.
  • Alkindi S; Department of Haematology, Sultan Qaboos University Hospital, Oman; College of Medicine and Health Sciences, Muscat, Oman. Electronic address: usesskindi@squ.edu.om.
  • Elsadek RA; Department of Medicine-Nizwa Hospital, Nizwa, Oman.
  • Al-Madhani A; Department of Medicine, Sohar Hospital, Sohar, Oman.
  • Al-Musalhi M; Laboratory Department, Ibra Hospital, Ibra, Oman.
  • AlKindi SY; Department of Internal Medicine, Al-Nahdha Hospital, Muscat, Oman.
  • Al-Khadouri G; Department of Haematology, Sultan Qaboos University Hospital, Oman.
  • Al Rawahi B; Department of Haematology, Sultan Qaboos University Hospital, Oman.
  • Al-Ruqeishi S; Department of Haematology, Sultan Qaboos University Hospital, Oman.
  • Al-Yazeedi J; Department of Medicine, Buraimi Hospital, Oman.
  • Wali YA; Paediatric Haematology Unit, Child Health Department, College of Medicine, Sultan Qaboos University Oman.
  • Al Shamakhi S; Nutrition Department, Ministry of Health, Muscat, Oman.
  • Al Rawahi M; College of Medicine and Health Sciences, Muscat, Oman.
  • Pathare AV; Department of Haematology, Sultan Qaboos University Hospital, Oman. Electronic address: avp16@hotmail.com.
Int J Infect Dis ; 106: 128-133, 2021 May.
Article in English | MEDLINE | ID: covidwho-1279596
ABSTRACT

OBJECTIVES:

The study aimed to assess COVID-19 impact on the morbidity and mortality of vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients.

METHODS:

A prospective cohort study of 100 SCA patients; 50 with COVID-19 (COVID group) and 50 without (non-COVID group). All patients signed written informed consent.

RESULTS:

The COVID group had a significantly higher VOC episode median per year; 3 (IQR,1-6) vs 2 (IQR,2-12) (P < 0.05). The need for hospitalisation was similar in both groups. The non-COVID group had more history of culture-proven infection (P = 0.05). The COVID-group had more osteonecrosis (P < 0.05), splenic sequestration, splenomegaly and hepatic crisis (P = 0.05, 0.006, 0.02; respectively) and significantly higher (P < 0.05) symptoms of fever, cough, fatigue, abdominal pain and anosmia. Mean haemoglobin, lymphocyte subset, platelets, and reticulocytes were reduced in both groups, while lactate dehydrogenase and ferritin levels were significantly elevated. In the COVID group, the rise in white blood cell count, reticulocyte percentage, platelets and ferritin was subdued (P < 0.05). Two patients in the COVID group and 3 in the non-COVID group died; there was no statistically significant difference in mortality.

CONCLUSIONS:

Although COVID-19 may have triggered the onset of VOC, it did not significantly influence VOC-related morbidity or mortality in this SCA cohort.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Chest Syndrome / SARS-CoV-2 / COVID-19 / Anemia, Sickle Cell Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Adult / Female / Humans / Male Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Chest Syndrome / SARS-CoV-2 / COVID-19 / Anemia, Sickle Cell Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Adult / Female / Humans / Male Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article