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Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia.
Plaas, Mihkel; Seppa, Kadri; Gaur, Nayana; Kasenõmm, Priit; Plaas, Mario.
  • Plaas M; Tartu University Hospital, Ear Clinic, Kuperjanovi 1, 51003, Tartu, Estonia; University of Tartu, Institute of Clinical Medicine, L. Puusepa 8, 50406, Tartu, Estonia. Electronic address: mihkel.plaas@kliinikum.ee.
  • Seppa K; University of Tartu, Institute of Biomedicine and Translational Medicine, Department of Physiology, Ravila 19, 50411, Tartu, Estonia; University of Tartu, Institute of Biomedicine and Translational Medicine, Laboratory Animal Centre, Ravila 14B, 50411, Tartu, Estonia.
  • Gaur N; Friedrich Schiller University Jena, Hans Berger Department of Neurology, Am Klinikum 1, 07747, Jena, Germany.
  • Kasenõmm P; Tartu University Hospital, Ear Clinic, Kuperjanovi 1, 51003, Tartu, Estonia; University of Tartu, Institute of Clinical Medicine, L. Puusepa 8, 50406, Tartu, Estonia.
  • Plaas M; University of Tartu, Institute of Biomedicine and Translational Medicine, Department of Physiology, Ravila 19, 50411, Tartu, Estonia; University of Tartu, Institute of Biomedicine and Translational Medicine, Laboratory Animal Centre, Ravila 14B, 50411, Tartu, Estonia. Electronic address: mario.plaas
Virology ; 561: 65-68, 2021 09.
Article in English | MEDLINE | ID: covidwho-1279712
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ABSTRACT
The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation / Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Nasal Mucosa Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Virology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation / Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 / Nasal Mucosa Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Virology Year: 2021 Document Type: Article