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Predication of oxygen requirement in COVID-19 patients using dynamic change of inflammatory markers: CRP, hypertension, age, neutrophil and lymphocyte (CHANeL).
Lee, Eunyoung Emily; Hwang, Woochang; Song, Kyoung-Ho; Jung, Jongtak; Kang, Chang Kyung; Kim, Jeong-Han; Oh, Hong Sang; Kang, Yu Min; Lee, Eun Bong; Chin, Bum Sik; Song, Woojeung; Kim, Nam Joong; Park, Jin Kyun.
  • Lee EE; Division of Rheumatology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu-Si, Gyeonggi-do, South Korea.
  • Hwang W; Hanyang Biomedical Research Institute, Hanyang University, Seoul, South Korea.
  • Song KH; Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
  • Jung J; Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
  • Kang CK; Division of Infectious Diseases, Department of Internal Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
  • Kim JH; Division of Infectious Diseases, Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam-Si, Gyeonggi-do, South Korea.
  • Oh HS; Division of Infectious Diseases, Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam-Si, Gyeonggi-do, South Korea.
  • Kang YM; Department of Infectious Diseases, Myongji Hospital, Goyang, Gyeonggi-do, South Korea.
  • Lee EB; Department of Medical Education, Seoul National University College of Medicine, Seoul, South Korea.
  • Chin BS; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
  • Song W; Division of Infectious Diseases, Department of Internal Medicine, National Medical Center, Seoul, South Korea.
  • Kim NJ; Department of Medicine, Major in Medical Genetics, Graduate School, Hanyang University, Seoul, South Korea.
  • Park JK; Division of Infectious Diseases, Department of Internal Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. molder@unitel.co.kr.
Sci Rep ; 11(1): 13026, 2021 06 22.
Article in English | MEDLINE | ID: covidwho-1279902
ABSTRACT
The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk of requiring oxygen support based on five parameters C-reactive protein (CRP), hypertension, age, and neutrophil and lymphocyte counts (CHANeL). This retrospective cohort study included 221 consecutive COVID-19 patients and the patients were randomly assigned randomly to a training set and a test set in a ratio of 11. Logistic regression, logistic LASSO regression, Random Forest, Support Vector Machine, and XGBoost analyses were performed based on age, hypertension status, serial CRP, and neutrophil and lymphocyte counts during the first 3 days of hospitalization. The ability of the model to predict oxygen requirement during hospitalization was tested. During hospitalization, 45 (41.8%) patients in the training set (n = 110) and 41 (36.9%) in the test set (n = 111) required supplementary oxygen support. The logistic LASSO regression model exhibited the highest AUC for the test set, with a sensitivity of 0.927 and a specificity of 0.814. An online risk calculator for oxygen requirement using CHANeL predictors was developed. "CHANeL" prediction models based on serial CRP, neutrophil, and lymphocyte counts during the first 3 days of hospitalization, along with age and hypertension status, provide a reliable estimate of the risk of supplement oxygen requirement among patients hospitalized with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen Inhalation Therapy / C-Reactive Protein / Lymphocytes / COVID-19 / Hypertension / Neutrophils Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92418-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen Inhalation Therapy / C-Reactive Protein / Lymphocytes / COVID-19 / Hypertension / Neutrophils Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92418-2