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Cycle Thresholds Among Solid Organ Transplant Recipients Testing Positive for SARS-CoV-2.
Theodore, Deborah A; Greendyke, William G; Miko, Benjamin; Whittier, Susan; Green, Daniel A; Shoucri, Sherif; Verna, Elizabeth C; Zucker, Jason; Sobieszczyk, Magdalena E; Aaron, Justin G; Scully, Brian E; Saiman, Lisa; Pereira, Marcus; Furuya, E Yoko.
  • Theodore DA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Greendyke WG; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Miko B; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Whittier S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
  • Green DA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
  • Shoucri S; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Verna EC; Division of Digestive and Liver Diseases, Center for Liver Disease and Transplantation, Columbia University Irving Medical Center, New York, NY.
  • Zucker J; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Sobieszczyk ME; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.
  • Aaron JG; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Scully BE; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Saiman L; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Pereira M; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.
  • Furuya EY; Department of Infection Prevention and Control, NewYork-Presbyterian Hospital, New York, NY.
Transplantation ; 105(7): 1445-1448, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1280174
ABSTRACT

BACKGROUND:

The optimal duration of transmission-based precautions among immunocompromised patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown.

METHODS:

Retrospective review of patients with solid organ transplant with positive SARS-CoV-2 polymerase chain reaction result from nasopharyngeal specimens admitted to the hospital between March 13, 2020 and May 15, 2020.

RESULTS:

Twenty-one percent of solid organ transplant recipients with positive SARS-CoV-2 polymerase chain reaction detected ≥20 d after symptom onset (or after first positive test among asymptomatic individuals) had a low cycle threshold (ie, high viral load). The majority of these patients were asymptomatic or symptomatically improved.

CONCLUSIONS:

Solid organ transplant recipients may have prolonged high viral burden of SARS-CoV-2. Further data are needed to understand whether cycle threshold data can help inform strategies for prevention of healthcare-associated transmission of SARS-CoV-2 and for appropriate discontinuation of transmission-based precautions.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Postoperative Complications / Organ Transplantation / Viral Load / COVID-19 Testing / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Transplantation Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Postoperative Complications / Organ Transplantation / Viral Load / COVID-19 Testing / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Transplantation Year: 2021 Document Type: Article