Neuromuscular complications of coronavirus disease-19.
Curr Opin Neurol
; 34(5): 669-674, 2021 10 01.
Article
in English
| MEDLINE | ID: covidwho-1280182
ABSTRACT
PURPOSE OF REVIEW Since its outbreak in Wuhan, China in late 2019, coronavirus disease-19 (COVID-19) has become a global pandemic. The number of affected cases and deaths continues to rise. Primarily a respiratory illness, COVID-19 is now known to affect various organ systems including peripheral nerve and skeletal muscle. The purpose of this review is to discuss the scope of neuromuscular manifestations and complications of COVID-19. RECENT FINDINGS:
Several neuromuscular conditions, including Guillain-Barré syndrome, rhabdomyolysis, and myositis, have been reported in patients infected with COVID-19, but even with a temporal association, a causal relationship remains unproven. Direct invasion of neurons or myocytes by the virus, and immune-mediated injury have been speculated but not consistently demonstrated. In addition to potentially causing the above conditions, COVID-19 can trigger exacerbations of preexisting neuromuscular conditions such as myasthenia gravis, and severe infections can lead to critical illness myopathy/polyneuropathy.SUMMARY:
COVID-19 appears to be potentially associated with a wide range of neuromuscular manifestations and complications. Further studies are needed to examine these possible associations, understand the pathogenesis, and develop preventive and treatment strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Muscular Diseases
/
Myasthenia Gravis
/
Neuromuscular Diseases
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Curr Opin Neurol
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
WCO.0000000000000970
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