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Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19.
Lind, Eric; Jameson, Andrew; Kurban, Esaw.
  • Lind E; Mercy Health St. Mary's Division of Infectious Disease and Michigan State University College of Human Medicine Department of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA linderic@msu.edu.
  • Jameson A; Mercy Health St. Mary's Division of Infectious Disease and Michigan State University College of Human Medicine Department of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA.
  • Kurban E; Mercy Health St. Mary's Division of Infectious Disease and Michigan State University College of Human Medicine Department of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA.
BMJ Case Rep ; 14(6)2021 Jun 21.
Article in English | MEDLINE | ID: covidwho-1280407
ABSTRACT
A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. The diagnosis of diffuse alveolar haemorrhage secondary to GPA was confirmed with labs, imaging and histopathology. Precipitous deterioration of GPA with concurrent COVID-19 infection indicates a possible temporal relationship. Since the onset of the pandemic, SARS-CoV-2 has been anecdotally associated with the development of various connective tissue disorders. The overlapping clinical presentations and similar appearance on lung imaging present clinicians with a diagnostic challenge. This underscores the importance of having a high index of suspicion of autoimmune diagnoses in patients who present with new or worsening findings following a COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Granulomatosis with Polyangiitis / COVID-19 / Lung Diseases Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-242628

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Granulomatosis with Polyangiitis / COVID-19 / Lung Diseases Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-242628