Endothelial metabolism in pulmonary vascular homeostasis and acute respiratory distress syndrome.
Am J Physiol Lung Cell Mol Physiol
; 321(2): L358-L376, 2021 08 01.
Article
in English
| MEDLINE | ID: covidwho-1280497
ABSTRACT
Capillary endothelial cells possess a specialized metabolism necessary to adapt to the unique alveolar-capillary environment. Here, we highlight how endothelial metabolism preserves the integrity of the pulmonary circulation by controlling vascular permeability, defending against oxidative stress, facilitating rapid migration and angiogenesis in response to injury, and regulating the epigenetic landscape of endothelial cells. Recent reports on single-cell RNA-sequencing reveal subpopulations of pulmonary capillary endothelial cells with distinctive reparative capacities, which potentially offer new insight into their metabolic signature. Lastly, we discuss broad implications of pulmonary vascular metabolism on acute respiratory distress syndrome, touching on emerging findings of endotheliitis in coronavirus disease 2019 (COVID-19) lungs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Endothelium, Vascular
/
Pulmonary Circulation
/
SARS-CoV-2
/
COVID-19
/
Neovascularization, Pathologic
Type of study:
Observational study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Am J Physiol Lung Cell Mol Physiol
Journal subject:
Molecular Biology
/
Physiology
Year:
2021
Document Type:
Article
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