COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation.
PLoS One
; 16(6): e0253465, 2021.
Article
in English
| MEDLINE | ID: covidwho-1280631
ABSTRACT
INTRODUCTION:
This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable mortality and need for mechanical ventilation) in patients hospitalized in Galicia with COVID-19 pneumonia.METHODS:
Retrospective, multicenter, observational study carried out in the 8 Galician tertiary hospitals. All Patients admitted with confirmed COVID-19 pneumonia from 1st of March to April 24th, 2020 were included. A multivariable logistic regression analysis was performed in order to identify the relationship between risk factors, therapeutic interventions and the composite outcome variable.RESULTS:
A total of 1292 patients (56.1% male) were included. Two hundred and twenty-five (17.4%) died and 327 (25.3%) reached the main outcome variable. Age [odds ratio (OR) = 1.03 (95% confidence interval (CI) 1.01-1.04)], CRP quartiles 3 and 4 [OR = 2.24 (95% CI 1.39-3.63)] and [OR = 3.04 (95% CI 1.88-4.92)], respectively, Charlson index [OR = 1.16 (95%CI 1.06-1.26)], SaO2 upon admission [OR = 0.93 (95% CI 0.91-0.95)], hydroxychloroquine prescription [OR = 0.22 (95%CI 0.12-0.37)], systemic corticosteroids prescription [OR = 1.99 (95%CI 1.45-2.75)], and tocilizumab prescription [OR = 3.39 (95%CI 2.15-5.36)], significantly impacted the outcome. Sensitivity analysis using different alternative logistic regression models identified consistently the ratio admissions/hospital beds as a predictor of the outcome [OR = 1.06 (95% CI 1.02-1.11)].CONCLUSION:
These findings may help to identify patients at hospital admission with a higher risk of death and may urge healthcare authorities to implement policies aimed at reducing deaths by increasing the availability of hospital beds.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
PLoS One
Journal subject:
Science
/
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Journal.pone.0253465
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