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COVID-19-associated Guillain-Barre syndrome: Postinfectious alone or neuroinvasive too?
Khan, Farman; Sharma, Praveen; Pandey, Saurabh; Sharma, Deepak; V, Vijayavarman; Kumar, Neeraj; Shukla, Suruchi; Dandu, Himanshu; Jain, Amita; Garg, Ravindra K; Malhotra, Hardeep S.
  • Khan F; Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Sharma P; Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Pandey S; Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Sharma D; Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • V V; Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Kumar N; Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Shukla S; Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Dandu H; Department of Infectious Diseases, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Jain A; Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Garg RK; Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
  • Malhotra HS; Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
J Med Virol ; 93(10): 6045-6049, 2021 10.
Article in English | MEDLINE | ID: covidwho-1281226
ABSTRACT
Coronavirus disease 2019 (COVID-19) has been shown to be associated with a lot of neurological complications, of whom Guillain-Barre syndrome (GBS) is an important post-infectious consequentiality. More than 220 patients with GBS have been reported thus far. We intend to share our experience with five patients of GBS where one of them had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the cerebrospinal fluid (CSF). This is the first-ever report demonstrating the presence of SARS-CoV-2 in the CSF of an adult patient; a similar occurrence has recently been described in a pediatric patient. We wish to emphasize the fact that commonly GBS occurs as a result of a post-infectious process but in a few cases where the symptoms of COVID-19 and GBS occur concurrently, corresponding to the viremic phase, separate pathogenesis needs to be thought of. This para-infectious nature is exemplified by the presence of virus in the cerebrospinal fluid of one of our patients. We review the neuroinvasive potential of SARS-Cov-2 in this regard and draw parallels with Cytomegalovirus, Zika virus, and Human Immunodeficiency virus-associated occurrences of GBS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Risk factors Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27159

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Risk factors Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27159