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Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic.
Dewanjee, Saikat; Vallamkondu, Jayalakshmi; Kalra, Rajkumar Singh; Puvvada, Nagaprasad; Kandimalla, Ramesh; Reddy, P Hemachandra.
  • Dewanjee S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India. saikat.dewanjee@jadavpuruniversity.in.
  • Vallamkondu J; National Institute of Technology, Warangal, 506004, Telangana, India.
  • Kalra RS; AIST-INDIA DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), Higashi 1-1-1, Tsukuba, 305 8565, Japan.
  • Puvvada N; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.
  • Kandimalla R; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 50000, Telangana, India.
  • Reddy PH; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 50000, Telangana, India. ramesh.kandimalla@gmail.com.
Mol Neurobiol ; 58(9): 4694-4715, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1281328
ABSTRACT
The unremitting coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marked a year-long phase of public health adversaries and has severely compromised healthcare globally. Early evidence of COVID-19 noted its impact on the pulmonary and cardiovascular functions, while multiple studies in recent time shed light on its substantial neurological complications, though a comprehensive understanding of the cause(s), the mechanism(s), and their neuropathological outcomes is scarce. In the present review, we conferred evidence of neurological complications in COVID-19 patients and shed light on the SARS-CoV-2 infection routes including the hematogenous, direct/neuronal, lymphatic tissue or cerebrospinal fluid, or infiltration through infected immune cells, while the underlying mechanism of SARS-CoV-2 invasion to the central nervous system (CNS) was also discussed. In an up-to-date manner, we further reviewed the impact of COVID-19 in developing diverse neurologic manifestations associated with CNS, peripheral nervous system (PNS), skeletal muscle, and also pre-existing neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and myasthenia gravis. Furthermore, we discussed the involvement of key factors including age, sex, comorbidity, and disease severity in exacerbating the neurologic manifestations in COVID-19 patients. An outlook of present therapeutic strategies and state of existing challenges in COVID-19 management was also accessed. Conclusively, the present report provides a comprehensive review of COVID-19-related neurological complications and emphasizes the need for their early clinical management in the ongoing COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Etiology study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Child / Female / Humans / Male / Middle aged Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02450-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Etiology study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Child / Female / Humans / Male / Middle aged Language: English Journal: Mol Neurobiol Journal subject: Molecular Biology / Neurology Year: 2021 Document Type: Article Affiliation country: S12035-021-02450-6