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Inactivation of SARS-CoV-2 by Ozonated Glycerol.
Takeda, Yohei; Jamsransuren, Dulamjav; Makita, Yoshimasa; Kaneko, Akihiro; Matsuda, Sachiko; Ogawa, Haruko; Oh, Hourei.
  • Takeda Y; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
  • Jamsransuren D; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
  • Makita Y; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
  • Kaneko A; Department of Chemistry, Osaka Dental University, 8-1 Kuzuha Hanazono Hirakata, Osaka, 573-1121, Japan.
  • Matsuda S; Department of Oral Surgery, Ikegami General Hospital, 6-1-19 Ikegami Ootaku, Tokyo, 146-8531, Japan.
  • Ogawa H; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
  • Oh H; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
Food Environ Virol ; 13(3): 316-321, 2021 09.
Article in English | MEDLINE | ID: covidwho-1281335
ABSTRACT
We evaluated the SARS-CoV-2-inactivation activity of ozonated glycerol (OG). When a viral solution with 1% fetal bovine serum (FBS) was mixed with test solutions at a ratio of 119 and incubated for 20 s, OG with ozone concentrations of over 1000 ppm inactivated ≥ 94.38% of the virus. Extension of the reaction time to 1 h led to the inactivation of ≥ 99.82% of the virus (the viral titer was below the detection limit). Extension to 24 h resulted in concentrations over 200 ppm OG inactivating ≥ 99.87% of the virus (the viral titers were below the detection limit). Next, viral solutions with 1, 20, and 40% FBS were mixed with test solutions at a ratio of 119 and incubated for 5 min. Whereas the virucidal activity of 500 ppm OG was very limited in the presence of 1% FBS (79.47% inactivation), it increased in the presence of 20 and 40% FBS (95.13 and 97.95% inactivation, respectively; the viral titers were not below the detection limit). Meanwhile, over 1000 ppm OG inactivated ≥ 99.44% of the virus regardless of the FBS concentration (the viral titers were below the detection limit). Extension of the reaction time to 1 h led to 500 ppm OG inactivating ≥ 99.91 and ≥ 99.95% of the virus with 20 and 40% FBS, respectively (the viral titers were below the detection limit). These results suggested that OG might be useful as a virucidal agent against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Ozone / Hand Hygiene / Hand Sanitizers / SARS-CoV-2 / COVID-19 / Glycerol Type of study: Experimental Studies Limits: Animals Language: English Journal: Food Environ Virol Year: 2021 Document Type: Article Affiliation country: S12560-021-09485-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Ozone / Hand Hygiene / Hand Sanitizers / SARS-CoV-2 / COVID-19 / Glycerol Type of study: Experimental Studies Limits: Animals Language: English Journal: Food Environ Virol Year: 2021 Document Type: Article Affiliation country: S12560-021-09485-x