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Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19.
Magomedov, Abakar; Zickler, Daniel; Karaivanov, Stoyan; Kurreck, Annika; Münch, Frédéric H; Kamhieh-Milz, Julian; Ferse, Caroline; Kahl, Andreas; Piper, Sophie K; Eckardt, Kai-Uwe; Dörner, Thomas; Kruse, Jan Matthias.
  • Magomedov A; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Zickler D; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Karaivanov S; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Kurreck A; Department of Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Münch FH; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Kamhieh-Milz J; Department of Transfusion Medince, Universitätsmedizin Berlin, Berlin, Germany.
  • Ferse C; Wimedko GmbH, Manfred-von-Richthofen Str. 15, 12101, Berlin, Germany.
  • Kahl A; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Piper SK; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Eckardt KU; Institute of Biometry and Clinical Epidemiology, Charité-Universitätmedizin Berlin, Berlin, Germany.
  • Dörner T; Berlin Institute of Health (BIH), Anna-Louisa-Karsch 2, 10178, Berlin, Germany.
  • Kruse JM; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sci Rep ; 11(1): 13325, 2021 06 25.
Article in English | MEDLINE | ID: covidwho-1281739
ABSTRACT
COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM) in a single center cohort of 13 critical ill patients and performed follow up examinations three months after discharge from ICU. We found clear signs of a hypercoagulable state due to severe hypofibrinolysis and a high rate of thromboembolic complications during the phase of acute illness. Three month follow up revealed normalization of the initial coagulation abnormality and no evidence of venous thrombosis in all thirteen patients. In our cohort the coagulation profile was completely normalized three months after COVID-19. Based on these findings, discontinuation of anticoagulation can be discussed in patients with complete venous reperfusion.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombelastography / Thromboembolism / Blood Coagulation Disorders / Venous Thrombosis / COVID-19 / COVID-19 Drug Treatment / Anticoagulants Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92683-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombelastography / Thromboembolism / Blood Coagulation Disorders / Venous Thrombosis / COVID-19 / COVID-19 Drug Treatment / Anticoagulants Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92683-1