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Concise Synthesis of Both Enantiomers of Pilocarpine.
Schmidt, Theresa; Heise, Niels; Merzweiler, Kurt; Deigner, Hans-Peter; Al-Harrasi, Ahmed; Csuk, René.
  • Schmidt T; Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
  • Heise N; Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
  • Merzweiler K; Department of Inorganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
  • Deigner HP; Medical and Life Science Faculty, Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle, Str. 17, D-78054 Villingen-Schwenningen, Germany.
  • Al-Harrasi A; Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, PC 616 Nizwa, Oman.
  • Csuk R; Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
Molecules ; 26(12)2021 Jun 16.
Article in English | MEDLINE | ID: covidwho-1282539
ABSTRACT
Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pilocarpine / 4-Butyrolactone / Furans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26123676

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pilocarpine / 4-Butyrolactone / Furans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26123676