HIV-1 Persistence in Children during Suppressive ART.
Viruses
; 13(6)2021 06 12.
Article
in English
| MEDLINE | ID: covidwho-1282640
ABSTRACT
There is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during pregnancy play a role in reservoir establishment. Children that initiated early antiretroviral therapy (ART) and maintained long-term suppression of viremia have smaller and less diverse HIV reservoirs than adults, although their proviral landscape during ART is reported to be similar to that of adults. The ability of these early infected cells to persist long-term through clonal expansion poses a major barrier to finding a cure. Furthermore, the effects of life-long HIV persistence and ART are yet to be understood, but growing evidence suggests that these individuals are at an increased risk for developing non-AIDS-related comorbidities, which underscores the need for an HIV cure.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disease Reservoirs
/
HIV Infections
/
HIV-1
/
Antiretroviral Therapy, Highly Active
/
Anti-Retroviral Agents
Type of study:
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Pregnancy
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
V13061134
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