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Potential severe pediatric SARS-CoV-2-induced multisystem inflammatory syndrome resembles dengue infection.
Yuliarto, S; Susanto, W P; Kadafi, K T; Ratridewi, I; Olivianto, E.
  • Yuliarto S; Department of Pediatrics, Saiful Anwar General Hospital, Universitas Brawijaya Malang, Indonesia.
  • Susanto WP; Department of Pediatrics, Saiful Anwar General Hospital, Universitas Brawijaya Malang, Indonesia.
  • Kadafi KT; Department of Pediatrics, Saiful Anwar General Hospital, Universitas Brawijaya Malang, Indonesia.
  • Ratridewi I; Department of Pediatrics, Saiful Anwar General Hospital, Universitas Brawijaya Malang, Indonesia.
  • Olivianto E; Department of Pediatrics, Saiful Anwar General Hospital, Universitas Brawijaya Malang, Indonesia.
Trop Biomed ; 38(2): 129-133, 2021 Jun 01.
Article in English | MEDLINE | ID: covidwho-1282843
ABSTRACT
We describe a child with acute fever and abdominal pain who developed rash and edema of extremities. Blood test revealed thrombocytopenia, lymphopenia, positive dengue-IgM, and hypoalbuminemia with elevated procalcitonin. Right pleural effusion revealed from chest x-ray. Diagnosed as dengue hemorrhagic fever (DHF) grade 1, however, at 7th day of illness, altered mental status, respiratory and circulatory failure occurred. Laboratory examination showed marked thrombocytopenia, transaminitis, metabolic acidosis, elevated D-dimer, decrease fibrinogen, and elevated cardiac marker (troponin I and CKMB). The patient then developed catecholamine-resistant shock and did not survive after 48 hours. Although rapid test of SARS CoV-2 infection was negative, rapid deterioration with some unusual clinical feature suggest multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection. This case raises an awareness of MIS-C that clinical features resemble dengue infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / Severe Dengue / Diagnostic Errors / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Limits: Child / Female / Humans Language: English Journal: Trop Biomed Journal subject: Tropical Medicine / Parasitology Year: 2021 Document Type: Article Affiliation country: Tb.38.2.048

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / Severe Dengue / Diagnostic Errors / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Limits: Child / Female / Humans Language: English Journal: Trop Biomed Journal subject: Tropical Medicine / Parasitology Year: 2021 Document Type: Article Affiliation country: Tb.38.2.048