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Network pharmacology-based analysis reveals the putative action mechanism of polygonum cuspidatum against COVID-19
International Journal of Clinical and Experimental Medicine ; 14(5):1852-1863, 2021.
Article in English | EMBASE | ID: covidwho-1283187
ABSTRACT

Background:

To evaluate the potential pharmacological activity of polygonum cuspidatum, a popular Chinese herb medicine (CHM), against COVID-19.

Methods:

The TCMSP database was utilized to screen the active ingredients and potential drug-targets of polygonum cuspidatum. Then GO/KEGG enrichment analysis of these common targets was performed, followed with the protein-protein interaction (PPI) network construction and core target extraction by Cytoscape and MCODE plugin, respectively. The molecular docking analysis was conducted by using CB-Dock. Furthermore, a newly developed TCMATCOV platform was employed to predict therapeutic effects of polygonum cuspidatum for COVID-19.

Results:

Fifteen key ingredients and 62 common targets were obtained from the above screening. The GO/KEGG enrichment analyses of these common targets and the core targets extracted from the PPI network suggested that polygonum cuspidatum had antiviral and immunoregulatory activities. Further molecular docking analysis showed that two key ingredients, physciondiglucoside and chrysophanol, had good binding affinities with the core targets, suggesting an important role for them in mediating the pharmacological activity of polygonum cuspidatum. The therapeutic effect of polygonum cuspidatum for COVID-19 was further validated by using the TCMATCOV platform.

Conclusion:

These results based on network pharmacology and bioinformatics analysis suggest polygonum cuspidatum is a promising CHM candidate against COVID-19.
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Collection: Databases of international organizations Database: EMBASE Language: English Journal: International Journal of Clinical and Experimental Medicine Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Language: English Journal: International Journal of Clinical and Experimental Medicine Year: 2021 Document Type: Article