Mitochondrial nanomedicine: Subcellular organelle-specific delivery of molecular medicines.
Nanomedicine
; 37: 102422, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1283501
ABSTRACT
As mitochondria network together to act as the master sensors and effectors of apoptosis, ATP production, reactive oxygen species management, mitophagy/autophagy, and homeostasis; this organelle is an ideal target for pharmaceutical manipulation. Mitochondrial dysfunction contributes to many diseases, for example, ß-amyloid has been shown to interfere with mitochondrial protein import and induce apoptosis in Alzheimer's Disease while some forms of Parkinson's Disease are associated with dysfunctional mitochondrial PINK1 and Parkin proteins. Mitochondrial medicine has applications in the treatment of an array of pathologies from cancer to cardiovascular disease. A challenge of mitochondrial medicine is directing therapies to a subcellular target. Nanotechnology based approaches combined with mitochondrial targeting strategies can greatly improve the clinical translation and effectiveness of mitochondrial medicine. This review discusses mitochondrial drug delivery approaches and applications of mitochondrial nanomedicines. Nanomedicine approaches have the potential to drive the success of mitochondrial therapies into the clinic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Nanomedicine
/
Alzheimer Disease
/
Mitochondria
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nanomedicine
Journal subject:
Biotechnology
Year:
2021
Document Type:
Article
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