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Immunologically relevant aspects of the new COVID-19 vaccines-an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper.
Untersmayr, Eva; Förster-Waldl, Elisabeth; Bonelli, Michael; Boztug, Kaan; Brunner, Patrick M; Eiwegger, Thomas; Eller, Kathrin; Göschl, Lisa; Grabmeier-Pfistershammer, Katharina; Hötzenecker, Wolfram; Jordakieva, Galateja; Moschen, Alexander R; Pfaller, Birgit; Pickl, Winfried; Reinisch, Walter; Wiedermann, Ursula; Klimek, Ludger; Bergmann, Karl-Christian; Brehler, Randolf; Pfützner, Wolfgang; Novak, Natalija; Merk, Hans; Rabe, Uta; Schlenter, Wolfgang; Ring, Johannes; Wehrmann, Wolfgang; Mülleneisen, Norbert; Wrede, Holger; Fuchs, Thomas; Jensen-Jarolim, Erika.
  • Untersmayr E; Institute of Pathophysiology and Allergy Research, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
  • Förster-Waldl E; Department of Neonatology, Paediatric Intensive Care Medicine and Neuropaediatrics with Centre for Congenital Immunodeficiencies, University Clinics of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Bonelli M; Clinical Department of Rheumatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Boztug K; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
  • Brunner PM; St. Anna Children's Hospital and University Clinic for Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Eiwegger T; St. Anna Kinderkrebsforschung GmbH, Vienna, Austria.
  • Eller K; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Göschl L; University Clinics of Dermatology, Medical University of Vienna, Vienna, Austria.
  • Grabmeier-Pfistershammer K; Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario Canada.
  • Hötzenecker W; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario Canada.
  • Jordakieva G; Clinical Department of Pediatrics, University Hospital St. Pölten, St. Pölten, Austria.
  • Moschen AR; Clinical Department of Nephrology, Internal Medicine, Medical University of Graz, Graz, Austria.
  • Pfaller B; Clinical Department of Rheumatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Pickl W; Institute of Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Reinisch W; University Clinics of Dermatology and Venereology, Kepler University Hospital, Comprehensive Allergy Centre, Linz, Austria.
  • Wiedermann U; University Clinics of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
  • Klimek L; University Clinics of Internal Medicine, Department of Gastroenterology and Hepatology, Kepler University Hospital, Linz, Austria.
  • Bergmann KC; Department of Internal Medicine 1, Karl Landsteiner University of Health Sciences, University Hospital, St. Pölten, Austria.
  • Brehler R; Institute of Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Pfützner W; Clinical Division of Gastroenterology and Hepatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Novak N; Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Merk H; Centre for Rhinology and Allergology, Wiesbaden, Germany.
  • Rabe U; Department of Dermatology, Venereology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Schlenter W; Department of Skin Diseases-General Dermatology and Venereology-Outpatient Clinic for Allergology, Occupational Dermatology and Environmental Medicine, University Hospital Münster, Münster, Germany.
  • Ring J; Department of Dermatology and Allergology, University Hospital Marburg (UKGM), Philipps University Marburg, Marburg, Germany.
  • Wehrmann W; Clinic and Polyclinic for Dermatology and Allergology, University Hospital Bonn, Bonn, Germany.
  • Mülleneisen N; Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany.
  • Wrede H; Clinic for Allergology, Johanniter-Krankenhaus im Fläming Treuenbrietzen GmbH, Treuenbrietzen, Germany.
  • Fuchs T; AeDA-Ärzteverband Deutscher Allergologen, Langen-Dreieich, Germany.
  • Jensen-Jarolim E; Skin and Laser Centre at the Opera, Munich, Germany.
Allergo J Int ; 30(5): 155-168, 2021.
Article in English | MEDLINE | ID: covidwho-1283828
ABSTRACT

BACKGROUND:

The vaccines against the coronavirus disease 2019 (COVID-19) approved in the European Union represent a decisive step in the fight against the pandemic. The application of these available vaccines to patients with pre-existing immunological conditions leads to a multitude of questions regarding efficacy, side effects and the necessary patient information.

RESULTS:

This review article provides insight into mechanisms of action of the currently available severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and summarises the current state of science as well as expert recommendations regarding tolerability of the vaccines. In addition, the potential to develop protective immune responses is determined. A special focus is given on patients under immunosuppression or in treatment with immunomodulatory drugs. Special groups of the population such as children, pregnant women and the elderly are also considered.

CONCLUSION:

Despite the need for a patient-specific risk-benefit assessment, the consensus among experts is that patients with immunological diseases in particular benefit from the induced immune protection after COVID-19 vaccination and do not have an increased risk of side effects.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Allergo J Int Year: 2021 Document Type: Article Affiliation country: S40629-021-00178-2

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Allergo J Int Year: 2021 Document Type: Article Affiliation country: S40629-021-00178-2