Prevalence and impact of comorbidities on disease prognosis among patients with COVID-19 in Bangladesh: A nationwide study amid the second wave.
Diabetes Metab Syndr
; 15(4): 102148, 2021.
Article
in English
| MEDLINE | ID: covidwho-1284040
ABSTRACT
BACKGROUND:
Socio-demographics and comorbidities are involved in determining the severity and fatality in patients with COVID-19 suggested by studies in various countries, but study in Bangladesh is insufficient.AIMS:
We designed the study to evaluate the association of sociodemographic and comorbidities with the prognosis of adverse health outcomes in patients with COVID-19 in Bangladesh.METHODS:
A multivariate retrospective cohort study was conducted on data from 966 RT-PCR positive patients from eight divisions during December 13, 2020, to February 13, 2021. Variables included sociodemographic, comorbidities, symptoms, Charlson comorbidity index (CCI) and access to health facilities. Major outcome was fatality. Secondary outcomes included hospitalization, duration of hospital stay, requirement of mechanical ventilation and severity.RESULTS:
Male (65.8%, 636 of 966) was predominant and mean age was 39.8 ± 12.6 years. Fever (79%), dry cough (55%), and loss of test/smell (51%) were frequent and 74% patients had >3 symptoms. Fatality was recorded in 10.5% patients. Comorbidities were found in 44% patients. Hypertension (21.5%) diabetes (14.6%), and cardiovascular diseases (11.3%) were most prevalent. Age >60 years (OR 4.83, 95% CI 2.45-6.49), and CCI >3 (OR 5.48, 95% CI 3.95-7.24) were predictors of hospitalizations. CCI >4 (aOR 3.41, 95% CI 2.57-6.09) was predictor of severity. Age >60 years (aOR 3.77, 95% CI 1.07-6.34), >3 symptoms (aOR 2.14, 95% CI 0.97-4.91) and CCI >3 vs. CCI <3 (aOR 5.23, 95% CI 3.77-8.09) were independently associated with fatality.CONCLUSIONS:
Increased age, >3 symptoms, increasing comorbidities, higher CCI were associated with increased hospitalization, severity and fatality in patients with COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Diabetes Mellitus
/
SARS-CoV-2
/
COVID-19
/
Hospitalization
/
Hypertension
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Country/Region as subject:
Asia
Language:
English
Journal:
Diabetes Metab Syndr
Year:
2021
Document Type:
Article
Affiliation country:
J.dsx.2021.05.021
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