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Graphene nanoplatelet and graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2.
De Maio, Flavio; Palmieri, Valentina; Babini, Gabriele; Augello, Alberto; Palucci, Ivana; Perini, Giordano; Salustri, Alessandro; Spilman, Patricia; De Spirito, Marco; Sanguinetti, Maurizio; Delogu, Giovanni; Rizzi, Laura Giorgia; Cesareo, Giulio; Soon-Shiong, Patrick; Sali, Michela; Papi, Massimiliano.
  • De Maio F; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Palmieri V; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • Babini G; Istituto dei Sistemi Complessi, CNR, Via dei Taurini 19, 00185 Rome, Italy.
  • Augello A; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario "A. Gemelli", Largo A. Gemelli, 8 00168 Rome, Italy.
  • Palucci I; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • Perini G; Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Salustri A; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Spilman P; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • De Spirito M; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • Sanguinetti M; Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Delogu G; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • Rizzi LG; ImmunityBio, LLC, Culver City, 440 Duley Road, El Segundo, California, CA 90245, USA.
  • Cesareo G; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
  • Soon-Shiong P; Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Sali M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.
  • Papi M; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
iScience ; 24(7): 102788, 2021 Jul 23.
Article in English | MEDLINE | ID: covidwho-1284161
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Recent advancements in bidimensional nanoparticles production such as graphene (G) and graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) against SARS-CoV-2 infection. The ability of G and GO to interact with microorganisms provides an opportunity to develop engineered textiles for use in PPE and limit the spread of COVID-19. PPE in current use in high-risk settings for COVID transmission provides only a physical barrier that decreases infection likelihood and does not inactivate the virus. Here, we show that virus pre-incubation with soluble GO inhibits SARS-CoV-2 infection of VERO cells. Furthermore, when G/GO-functionalized polyurethane or cotton was in contact SARS-CoV-2, the infectivity of the fabric was nearly completely inhibited. The findings presented here constitute an important innovative nanomaterial-based strategy to significantly increase PPE efficacy in protection against the SARS-CoV-2 virus that may implement water filtration, air purification, and diagnostics methods.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.102788

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.102788