Novel Formulations of the Antiviral Drug Favipiravir: Improving Permeability and Tabletability
Crystal Growth and Design
; 2021.
Article
in English
| Scopus | ID: covidwho-1284672
ABSTRACT
Recently, favipiravir, as a broad-spectrum antiviral drug, has gain more attention because it might be a candidate to remedy the coronavirus disease 2019 (COVID-19). To improve its poor permeability and tabletability, four multicomponent crystals of favipiravir (FPV) were prepared by a slow evaporation or liquid-assisted grinding method, including three cocrystals (FPV-theophylline, 11;FPV-saccharin, 11;FPV-5-fluorouracil, 11) and one salt (FPV-piperazine, 21). All of the crystal structures were solved by single-crystal X-ray diffraction. Interestingly, FPV-theophylline has a crystal structure similar to that of FPV, leading to similar properties, such as solubility, permeability, and tabletability. Except for FPV-theophylline, all of the other multicomponent crystals exhibit an enhanced permeability and tabletability. Our studies provide a new insight in overcoming the shortcomings of the important antiviral drug FPV. ©
Full text:
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Crystal Growth and Design
Year:
2021
Document Type:
Article
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