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100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19.
Lobo, Niyati; Brooks, Nathan A; Zlotta, Alexandre R; Cirillo, Jeffrey D; Boorjian, Stephen; Black, Peter C; Meeks, Joshua J; Bivalacqua, Trinity J; Gontero, Paolo; Steinberg, Gary D; McConkey, David; Babjuk, Marko; Alfred Witjes, J; Kamat, Ashish M.
  • Lobo N; Department of Urology, MD Anderson Cancer Center, Houston, TX, USA.
  • Brooks NA; Department of Urology, MD Anderson Cancer Center, Houston, TX, USA.
  • Zlotta AR; Division of Urology, Department of Surgery, Sinai Health System, University of Toronto, Toronto, ON, Canada.
  • Cirillo JD; Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University of Toronto and University Health Network, Toronto, ON, Canada.
  • Boorjian S; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, USA.
  • Black PC; Department of Urology, Mayo Clinic, Rochester, MN, USA.
  • Meeks JJ; Vancouver Prostate Centre, Vancouver, BC, Canada.
  • Bivalacqua TJ; Northwestern University School of Medicine, Chicago, IL, USA.
  • Gontero P; The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Steinberg GD; Division of Urology, Molinette Hospital, University of Torino School of Medicine, Torino, Italy.
  • McConkey D; Department of Urology, NYU Langone Health, New York, NY, USA.
  • Babjuk M; Johns Hopkins Greenberg Bladder Cancer Institute, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Alfred Witjes J; Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Kamat AM; Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Nat Rev Urol ; 18(10): 611-622, 2021 10.
Article in English | MEDLINE | ID: covidwho-1284696
ABSTRACT
Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various non-mycobacterial and viral infections. The non-specific effects of BCG occur via the induction of trained immunity and form the basis for the hypothesis that BCG vaccination could be used to protect against the severity of coronavirus disease 2019 (COVID-19). This Perspective article highlights key milestones in the 100-year history of BCG and projects its potential role in the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Adjuvants, Immunologic / COVID-19 Vaccines / COVID-19 / Immunotherapy Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans / Infant Language: English Journal: Nat Rev Urol Journal subject: Urology Year: 2021 Document Type: Article Affiliation country: S41585-021-00481-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Adjuvants, Immunologic / COVID-19 Vaccines / COVID-19 / Immunotherapy Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans / Infant Language: English Journal: Nat Rev Urol Journal subject: Urology Year: 2021 Document Type: Article Affiliation country: S41585-021-00481-1