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Breast Milk and Breastfeeding of Infants Born to SARS-CoV-2 Positive Mothers: A Prospective Observational Cohort Study.
Kunjumon, Bgee; Wachtel, Elena V; Lumba, Rishi; Quan, Michelle; Remon, Juan; Louie, Moi; Verma, Sourabh; Moffat, Michael A; Kouba, Insaf; Bennett, Terri-Ann; Mejia, Claudia Manzano De; Mally, Pradeep V; Lin, Xinhua; Hanna, Nazeeh.
  • Kunjumon B; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Wachtel EV; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Lumba R; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Quan M; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Remon J; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Louie M; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Verma S; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Moffat MA; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Kouba I; Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York.
  • Bennett TA; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York.
  • Mejia CM; Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York.
  • Mally PV; Department of Pediatrics, New York University Long Island School of Medicine, New York City, New York.
  • Lin X; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York.
  • Hanna N; Department of Pediatrics, New York University Long Island School of Medicine, New York City, New York.
Am J Perinatol ; 38(11): 1209-1216, 2021 09.
Article in English | MEDLINE | ID: covidwho-1284751
ABSTRACT

OBJECTIVE:

There are limited published data on the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus from mothers to newborns through breastfeeding or from breast milk. The World Health Organization released guidelines encouraging mothers with suspected or confirmed COVID-19 to breastfeed as the benefits of breastfeeding outweighs the possible risk of transmission. The objective of this study was to determine if SARS-CoV-2 was present in the breast milk of lactating mothers who had a positive SARS-CoV-2 nasopharyngeal swab test prior to delivery, and the clinical outcomes for their newborns. STUDY

DESIGN:

This was a single-center, observational, prospective cohort study. Maternal-newborn dyads that delivered at New York University Langone Hospital Brooklyn with confirmed maternal SARS-CoV-2 positive screen test at the time of admission were recruited for the study. Breast milk samples were collected during postpartum hospitalization and tested for the presence of SARS-CoV-2 genes N1 and N2 by two-step reverse transcription polymerase chain reaction. Additionally, the clinical characteristics of the maternal newborn dyad, results of nasopharyngeal SARS-CoV-2 testing, and neonatal follow-up data were collected.

RESULTS:

A total of 19 mothers were included in the study and their infants who were all fed breast milk. Breast milk samples from 18 mothers tested negative for SARS-CoV-2, and 1 was positive for SARS-CoV-2 RNA. The infant who ingested the breast milk that tested positive had a negative nasopharyngeal test for SARS-CoV-2, and had a benign clinical course. There was no evidence of significant clinical infection during the hospital stay or from outpatient neonatal follow-up data for all the infants included in this study.

CONCLUSION:

In a small cohort of SARS-CoV-2 positive lactating mothers giving birth at our institution, most of their breast milk samples (95%) contained no detectable virus, and there was no evidence of COVID-19 infection in their breast milk-fed neonates. KEY POINTS · Breast milk may rarely contain detectable SARS-CoV-2 RNA and was not detected in asymptomatic mothers.. · Breast milk with detectable SARS-CoV-2 RNA from a symptomatic mother had no clinical significance for her infant.. · Breast feeding with appropriate infection control instructions appears to be safe in mother with COVID infection..
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Breast Feeding / Infection Control / Infectious Disease Transmission, Vertical / SARS-CoV-2 / COVID-19 / Milk, Human Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Am J Perinatol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Breast Feeding / Infection Control / Infectious Disease Transmission, Vertical / SARS-CoV-2 / COVID-19 / Milk, Human Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Am J Perinatol Year: 2021 Document Type: Article