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Risk factors, symptom reporting, healthcare-seeking behaviour and adherence to public health guidance: protocol for Virus Watch, a prospective community cohort study.
Hayward, Andrew; Fragaszy, Ellen; Kovar, Jana; Nguyen, Vincent; Beale, Sarah; Byrne, Thomas; Aryee, Anna; Hardelid, Pia; Wijlaars, Linda; Fong, Wing Lam Erica; Geismar, Cyril; Patel, Parth; Shrotri, Madhumita; Navaratnam, Annalan M D; Nastouli, Eleni; Spyer, Moira; Killingley, Ben; Cox, Ingemar; Lampos, Vasileios; McKendry, Rachel A; Liu, Yunzhe; Cheng, Tao; Johnson, Anne M; Michie, Susan; Gibbs, Jo; Gilson, Richard; Rodger, Alison; Aldridge, Robert W.
  • Hayward A; Institute of Epidemiology and Health Care, University College London, London, UK a.hayward@ucl.ac.uk.
  • Fragaszy E; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Kovar J; Department of Infectious Disease Epidemiology, LSHTM, London, UK.
  • Nguyen V; Institute of Epidemiology and Health Care, University College London, London, UK.
  • Beale S; Institute of Epidemiology and Health Care, University College London, London, UK.
  • Byrne T; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Aryee A; Institute of Epidemiology and Health Care, University College London, London, UK.
  • Hardelid P; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Wijlaars L; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Fong WLE; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Geismar C; Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK.
  • Patel P; Population, Policy and Practice, University College London, London, UK.
  • Shrotri M; Primary Care and Population Health, University College London, London, UK.
  • Navaratnam AMD; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Nastouli E; Institute of Epidemiology and Health Care, University College London, London, UK.
  • Spyer M; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Killingley B; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Cox I; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Lampos V; Institute of Epidemiology and Health Care, University College London, London, UK.
  • McKendry RA; Centre for Public Health Data Science, Institute of Health Informatics, University College London, London, UK.
  • Liu Y; Population, Policy and Practice, University College London, London, UK.
  • Cheng T; Francis Crick Institute, London, UK.
  • Johnson AM; Population, Policy and Practice, University College London, London, UK.
  • Michie S; Francis Crick Institute, London, UK.
  • Gibbs J; University of Nottingham School of Medicine, Nottingham, UK.
  • Gilson R; University College London Hospital, London, UK.
  • Rodger A; Department of Computer Science, University College London, London, UK.
  • Aldridge RW; Department of Computer Science, University College London, London, UK.
BMJ Open ; 11(6): e048042, 2021 06 23.
Article in English | MEDLINE | ID: covidwho-1285085
ABSTRACT

INTRODUCTION:

The coronavirus (COVID-19) pandemic has caused significant global mortality and impacted lives around the world. Virus Watch aims to provide evidence on which public health approaches are most likely to be effective in reducing transmission and impact of the virus, and will investigate community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviours. METHODS AND

ANALYSIS:

Virus Watch is a household community cohort study of acute respiratory infections in England and Wales and will run from June 2020 to August 2021. The study aims to recruit 50 000 people, including 12 500 from minority ethnic backgrounds, for an online survey cohort and monthly antibody testing using home fingerprick test kits. Nested within this larger study will be a subcohort of 10 000 individuals, including 3000 people from minority ethnic backgrounds. This cohort of 10 000 people will have full blood serology taken between October 2020 and January 2021 and repeat serology between May 2021 and August 2021. Participants will also post self-administered nasal swabs for PCR assays of SARS-CoV-2 and will follow one of three different PCR testing schedules based on symptoms. ETHICS AND DISSEMINATION This study has been approved by the Hampstead National Health Service (NHS) Health Research Authority Ethics Committee (ethics approval number 20/HRA/2320). We are monitoring participant queries and using these to refine methodology where necessary, and are providing summaries and policy briefings of our preliminary findings to inform public health action by working through our partnerships with our study advisory group, Public Health England, NHS and government scientific advisory panels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Acceptance of Health Care / Public Health / Guideline Adherence / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-048042

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Acceptance of Health Care / Public Health / Guideline Adherence / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-048042