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Intestinal Barrier Biomarker ZO1 and Endotoxin Are Increased in Blood of Patients With COVID-19-associated Pneumonia.
Assimakopoulos, Stelios F; Mastronikolis, Stylianos; DE Lastic, Anne-Lise; Aretha, Diamanto; Papageorgiou, Dimitris; Chalkidi, Theodora; Oikonomou, Ioanna; Triantos, Christos; Mouzaki, Athanasia; Marangos, Markos.
  • Assimakopoulos SF; Department of Internal Medicine, University of Patras Medical School, Patras, Greece; sassim@upatras.gr.
  • Mastronikolis S; School of Medicine, University of Crete, Heraklion, Greece.
  • DE Lastic AL; Division of Hematology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Aretha D; Department of Anesthesiology and Intensive Care Medicine, University of Patras Medical School, Patras, Greece.
  • Papageorgiou D; Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Chalkidi T; Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Oikonomou I; Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Triantos C; Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Mouzaki A; Division of Hematology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
  • Marangos M; Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
In Vivo ; 35(4): 2483-2488, 2021.
Article in English | MEDLINE | ID: covidwho-1285631
ABSTRACT
BACKGROUND/

AIM:

The present study was undertaken to investigate (i) whether hospitalized patients with COVID-19 pneumonia present intestinal barrier dysfunction with consequent translocation of endotoxin into the systemic circulation and (ii) whether intestinal barrier biomarkers have any prognostic role in terms of progression to severe respiratory failure. PATIENTS AND

METHODS:

In this prospective study, 22 patients with COVID-19-associated pneumonia and 19 patients with non-COVID-19-related community-acquired pneumonia (CAP group) were studied while 12 healthy persons comprised the control group. Blood samples were collected on admission and analysed for serum levels of endotoxin and zonula occludens-1 (ZO1). Clinical courses regarding progression to severe respiratory failure (SRF) requiring mechanical ventilation were recorded.

RESULTS:

Patients with COVID-19-associated pneumonia and patients with CAP presented significantly higher serum endotoxin and ZO1 concentrations on admission as compared to healthy controls. There was no difference in endotoxin levels between patients with COVID-19-related pneumonia and patients with CAP. In patients with COVID-19-related pneumonia, serum endotoxin concentrations were positively correlated with C-reactive protein and ferritin values. There were no significant differences in serum endotoxin and ZO1 concentrations between patients with severe and not severe COVID-19-related pneumonia, nor between patients who developed SRF and those who did not

Conclusion:

Patients with COVID-19-related pneumonia present intestinal barrier dysfunction leading to systemic endotoxemia. Admission values of endotoxin and ZO1 do not have any prognostic role for progression to SRF.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: In Vivo Journal subject: Neoplasms Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: In Vivo Journal subject: Neoplasms Year: 2021 Document Type: Article