Your browser doesn't support javascript.
Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study.
Mahmoodpoor, Ata; Shadvar, Kamran; Sanaie, Sarvin; Hadipoor, Mir Reza; Pourmoghaddam, Mohammad Ata; Saghaleini, Seied Hadi.
  • Mahmoodpoor A; Fellowship of critical care medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shadvar K; Fellowship of critical care medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sanaie S; Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hadipoor MR; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pourmoghaddam MA; Yeditepe Dental Student Association Research Committee Member, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
  • Saghaleini SH; Fellowship of critical care medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Hsaghaleini@gmail.com.
BMC Infect Dis ; 21(1): 616, 2021 Jun 29.
Article in English | MEDLINE | ID: covidwho-1285992
ABSTRACT

BACKGROUND:

Critically ill patients frequently suffer from vitamin C deficiency. Previous studies showed that high doses of vitamin C administration had conflicting results on clinical outcomes in patients with severe sepsis, burns, and trauma. Because of the high incidence and morbidity/mortality with severe pneumonia, we aimed to investigate the effect of administration of high dose vitamin C in critically ill patients with severe pneumonia.

METHODS:

Eighty critically ill patients with pneumonia were enrolled in this randomized double-blinded clinical trial. Patients with a CURB-65 score > 3, one major criterion, or ≥ 3 minor criteria were considered as severe pneumonia. Patients were randomly assigned to intervention or placebo groups receiving standard treatment plus 60 mg/kg/day vitamin C as a continuous infusion or normal saline in the same volume correspondingly for 96 h. Serum levels of vitamin C were noted at baseline and 48 h after vitamin C administration. Duration of mechanical ventilation, ICU length of stay, PaO2/FiO2, and mortality rate were noted for all patients till the 28th day. Any complications related to the vitamin C administration were recorded.

RESULTS:

Duration of mechanical ventilation and vasopressor use were significantly lower in the intervention group (p < 0.001 and 0.003, respectively). Baseline levels of vitamin C in both groups did not have a significant difference but its levels increased in the intervention group and decreased in the control group during the study period. Mortality rate insignificantly decreased in the intervention group (p = 0.17). Three patients showed hypotension and tachycardia during the administration of vitamin C which was self-limited with decreasing the dose of vitamin C. Our results showed that the intravenous administration of a relatively high dose of vitamin C to critically ill patients with severe pneumonia was safe and could decrease the inflammation, duration of mechanical ventilation, and vasopressor use without any significant effect on mortality. TRIAL REGISTRATION IRCT registration number IRCT20190312043030N1, Registration date 2019-08-26, Seied Hadi Saghaleini.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Ascorbic Acid / Vitamins / Severity of Illness Index / Critical Care / Intensive Care Units Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06288-0

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Ascorbic Acid / Vitamins / Severity of Illness Index / Critical Care / Intensive Care Units Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06288-0