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The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19.
Tojo, Kentaro; Sugawara, Yoh; Oi, Yasufumi; Ogawa, Fumihiro; Higurashi, Takuma; Yoshimura, Yukihiro; Miyata, Nobuyuki; Hayami, Hajime; Yamaguchi, Yoshikazu; Ishikawa, Yoko; Takeuchi, Ichiro; Tachikawa, Natsuo; Goto, Takahisa.
  • Tojo K; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. ktojo@yokohama-cu.ac.jp.
  • Sugawara Y; Department of Anesthesiology, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Oi Y; Department of Emergency Medicine, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan.
  • Ogawa F; Department of Emergency Medicine, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan.
  • Higurashi T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan.
  • Yoshimura Y; Department of Infection Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Miyata N; Department of Infection Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Hayami H; Department of Anesthesiology, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Yamaguchi Y; Department of Anesthesiology, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Ishikawa Y; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
  • Takeuchi I; Department of Emergency Medicine, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan.
  • Tachikawa N; Department of Infection Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, 221-0085, Japan.
  • Goto T; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Sci Rep ; 11(1): 13431, 2021 06 28.
Article in English | MEDLINE | ID: covidwho-1286474
ABSTRACT
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that leads to severe respiratory failure (RF). It is known that host exposure to viral infection triggers an iron-lowering response to mitigate pathogenic load and tissue damage. However, the association between host iron-lowering response and COVID-19 severity is not clear. This two-center observational study of 136 adult hospitalized COVID-19 patients analyzed the association between disease severity and initial serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) levels. Serum iron levels were significantly lower in patients with mild RF than in the non-RF group; however, there were no significant differences in iron levels between the non-RF and severe RF groups, depicting a U-shaped association between serum iron levels and disease severity. TIBC levels decreased significantly with increasing severity; consequently, TSAT was significantly higher in patients with severe RF than in other patients. Multivariate analysis including only patients with RF adjusted for age and sex demonstrated that higher serum iron and TSAT levels were independently associated with the development of severe RF, indicating that inadequate response to lower serum iron might be an exacerbating factor for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Iron Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92921-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Iron Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-92921-6