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Colchicine use might be associated with lower mortality in COVID-19 patients: A meta-analysis.
Elshafei, Mohamed Nabil; El-Bardissy, Ahmed; Khalil, Ahmed; Danjuma, Mohammed; Mubasher, Mahmood; Abubeker, Ibrahim Y; Mohamed, Mouhand F H.
  • Elshafei MN; Clinical Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
  • El-Bardissy A; Clinical Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
  • Khalil A; Clinical Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
  • Danjuma M; College of Medicine, Qatar University, Doha, Qatar.
  • Mubasher M; Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Abubeker IY; Department of Internal Medicine, Rochester Regional Health, Unity Hospital of Rochester, Rochester, NY, USA.
  • Mohamed MFH; Alpert Medical School, Brown University, Providence, RI, USA.
Eur J Clin Invest ; 51(9): e13645, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1286673
ABSTRACT

BACKGROUND:

Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients. MATERIALS AND

METHODS:

We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model.

RESULTS:

Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group.

CONCLUSIONS:

This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Colchicine / Tubulin Modulators / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Eur J Clin Invest Year: 2021 Document Type: Article Affiliation country: Eci.13645

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Colchicine / Tubulin Modulators / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Eur J Clin Invest Year: 2021 Document Type: Article Affiliation country: Eci.13645