Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID19 (Review).
Mol Med Rep
; 24(2)2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1286942
ABSTRACT
Genetic and nongenetic factors associated with an increased inflammatory response may mediate a link between severe coronavirus disease 2019 (COVID19) and serious mental illness (SMI). However, systematic assessment of inflammatory responserelated factors associated with SMI that could influence COVID19 outcomes is lacking. In the present review, dietary patterns, smoking and the use of psychotropic medications are discussed as potential extrinsic risk factors and angiotensinconverting enzyme (ACE) insertion/deletion (I/D) gene polymorphisms are considered as potential intrinsic risk factors. A geneticsbased prediction model for SMI using ACEI/D genotyping is also proposed for use in patients experiencing severe COVID19. Furthermore, the literature suggests that ACE inhibitors may have protective effects against SMI or severe COVID19, which is often linked to hypertension and other cardiovascular comorbidities. For this reason, we hypothesize that using these medications to treat patients with severe COVID19 might yield improved outcomes, including in the context of SMI associated with COVID19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Mental Disorders
Type of study:
Prognostic study
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Mmr.2021.12250
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