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A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses.
Wu, Ming-Yu; Gu, Meijia; Leung, Jong-Kai; Li, Xinmei; Yuan, Yuncong; Shen, Chao; Wang, Lianrong; Zhao, Engui; Chen, Sijie.
  • Wu MY; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, 999077, China.
  • Gu M; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
  • Leung JK; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
  • Li X; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, 999077, China.
  • Yuan Y; College of Life Sciences and China Center for Type Culture Collection, Wuhan University, Wuhan, Hubei, 430071, China.
  • Shen C; College of Life Sciences and China Center for Type Culture Collection, Wuhan University, Wuhan, Hubei, 430071, China.
  • Wang L; College of Life Sciences and China Center for Type Culture Collection, Wuhan University, Wuhan, Hubei, 430071, China.
  • Zhao E; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
  • Chen S; School of Science, Harbin Institute of Technology, Shenzhen, HIT Campus of University Town, Shenzhen, 518055, China.
Small ; 17(30): e2101770, 2021 07.
Article in English | MEDLINE | ID: covidwho-1287404
ABSTRACT
COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in global social and economic disruption, putting the world economy to the largest global recession since the Great Depression. To control the spread of COVID-19, cutting off the transmission route is a critical step. In this work, the efficient inactivation of human coronavirus with photodynamic therapy (PDT) by employing photosensitizers with aggregation-induced emission characteristics (DTTPB) is reported. DTTPB is designed to bear a hydrophilic head and two hydrophobic tails, mimicking the structure of phospholipids on biological membranes. DTTPB demonstrates a broad absorption band covering the whole visible light range and high molar absorptivity, as well as excellent reactive oxygen species sensitizing ability, making it an excellent candidate for PDT. Besides, DTTPB can target membrane structure, and bind to the envelope of human coronaviruses. Upon light irradiation, DTTPB demonstrates highly effective antiviral behavior human coronavirus treated with DTTPB and white-light irradiation can be efficiently inactivated with complete loss of infectivity, as revealed by the significant decrease of virus RNA and proteins in host cells. Thus, DTTPB sensitized PDT can efficiently prevent the infection and the spread of human coronavirus, which provides a new avenue for photodynamic combating of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Photochemotherapy / COVID-19 Limits: Humans Language: English Journal: Small Journal subject: Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: Smll.202101770

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Photochemotherapy / COVID-19 Limits: Humans Language: English Journal: Small Journal subject: Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: Smll.202101770