Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS-CoV-2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)
Small
; 17(25):2170123, 2021.
Article
in English
| Wiley | ID: covidwho-1287405
ABSTRACT
In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co-workers report that thin, biological-grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS-CoV-2 viral spike and the ACE2-bound spike complex. GO nanosheets were shown to inhibit the infection of wild-type SARS-CoV-2 experimentally in cell cultures. Through an interplay of molecular dynamics simulations and cell biology, this work demonstrates that graphene oxide sheets could offer a platform to effectively interact and potentially transport other molecules to inactivate SARS-CoV-2.
Full text:
Available
Collection:
Databases of international organizations
Database:
Wiley
Language:
English
Journal:
Small
Year:
2021
Document Type:
Article
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