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Factors associated with COVID-19 and its outcome in patients with rheumatoid arthritis.
Malek Mahdavi, Aida; Varshochi, Mojtaba; Hajialilo, Mehrzad; Dastgiri, Saeed; Khabbazi, Raha; Khabbazi, Alireza.
  • Malek Mahdavi A; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Varshochi M; Department of Infectious Diseases, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hajialilo M; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Dastgiri S; Tabriz Health Services Management Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Khabbazi R; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Khabbazi A; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. dr_khabbazi@yahoo.com.
Clin Rheumatol ; 40(11): 4527-4531, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1287440
ABSTRACT

OBJECTIVE:

We assessed the factors associated with COVID-19, clinical manifestations, and a 30-day-prognosis of COVID-19 in a cohort of rheumatoid arthritis (RA) patients compared with the index population.

METHODS:

In a cross-sectional study, RA patients were followed in rheumatology clinics of Tabriz University of Medical Sciences, and a group of patients diagnosed with COVID-19 from index population were recruited. Outcomes of COVID-19 were assessed by the hospitalization rate and need to intensive care unit (ICU) and mortality. During a period of 12 weeks, 128 RA patients diagnosed with COVID-19, 760 RA control group, and 92 COVID-19 patients from index population were enrolled.

RESULTS:

Being female, obese, and diabetic, having pulmonary disease and chronic kidney disease (CKD), and treatment with prednisolone > 5 mg/d and TNFα inhibitors (TNFis) were independent predictors of COVID-19 in RA patients. Dyspnea, anosmia, and taste loss were more common in RA patients compared with the index population. Admission in hospital, need to ICU care, and mortality occurred in 38, 11.9, and 8.6 percent of RA patients, respectively. Although hospitalization rate in RA patients was more than the index population, there were no significant differences in need to ICU care and mortality between the two groups.

CONCLUSIONS:

Treatment with prednisolone and TNFis and having comorbidities including obesity, diabetes, pulmonary disease, and CKD increase the risk of COVID-19 in RA patients. Although some differences exist in the clinical manifestations of COVID-19 in RA patients and index population, prognosis of COVID-19 in RA patients is not any worse. Key Points • Being female, obese and diabetic, having pulmonary disease, chronic kidney disease (CKD), treatment with prednisolone > 5 mg/d and TNFα inhibitors (TNFis) were independent predictors of COVID-19 in RA patients. • Dyspnea, anosmia and taste loss were more common in RA patients compared with the index population. • Although COVID-19 related hospitalization was higher in RA patients than in the index population, there was no significant differences in the need to ICU care and mortality between the two groups.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Language: English Journal: Clin Rheumatol Year: 2021 Document Type: Article Affiliation country: S10067-021-05830-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans Language: English Journal: Clin Rheumatol Year: 2021 Document Type: Article Affiliation country: S10067-021-05830-4