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Tocilizumab for the treatment of non-critical COVID-19 pneumonia: an overview of the rationale and clinical evidence to date.
Kenny, Grace; Mallon, Patrick W G.
  • Kenny G; Centre for Experimental Pathogen Host Research, School of Medicine, University College Dublin, Dublin, Ireland.
  • Mallon PWG; Infectious Diseases Department, St Vincent's University Hospital, Dublin, Ireland.
Expert Rev Clin Pharmacol ; 14(10): 1279-1287, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1287936
ABSTRACT

Introduction:

Tocilizumab is one of the main repurposed therapies investigated for COVID-19 pneumonia since the start of the pandemic, but there has been conflicting evidence for its use.Areas covered This review covers the physiology of interleukin-6 and its role in the pathophysiology of COVID-19. We discuss the use of tocilizumab in other diseases and the rationale for its use in COVID-19. We summarize the design, contrasting results, and implications of the clinical trials of tocilizumab in COVID-19 to date and discuss the current guidance for its use.Expert opinion The evidence to date suggests benefit with the use of tocilizumab in some but not all patients with COVID-19. Benefit seems to be greatest when given early after clinical deterioration with the presence of systemic inflammation. However, questions remain around the optimal timing, patient selection, and concomitant treatments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Interleukin-6 / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Expert Rev Clin Pharmacol Year: 2021 Document Type: Article Affiliation country: 17512433.2021.1949286

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Interleukin-6 / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Expert Rev Clin Pharmacol Year: 2021 Document Type: Article Affiliation country: 17512433.2021.1949286