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Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?
Epstein, Rachel L; Sperring, Heather; Hofman, Melissa; Lodi, Sara; White, Laura F; Barocas, Joshua A; Bouton, Tara C; Xiao, Yian; Hsu, Heather E; Miller, Nancy S; Linas, Benjamin P; Marathe, Jai G.
  • Epstein RL; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Sperring H; Center for Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA.
  • Hofman M; Boston Medical Center, Boston, Massachusetts, USA.
  • Lodi S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • White LF; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Barocas JA; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Bouton TC; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Xiao Y; Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Hsu HE; Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Miller NS; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Linas BP; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Marathe JG; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Open Forum Infect Dis ; 8(6): ofab164, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1288086
ABSTRACT
To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid