Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study.
Front Aging Neurosci
; 13: 698184, 2021.
Article
in English
| MEDLINE | ID: covidwho-1288785
ABSTRACT
BACKGROUND:
The aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia. PATIENTS ANDMETHODS:
In a multicenter, observational, 12 matched case-control study all 23 patients with a history of dementia, hospitalized with a diagnosis of SARS-CoV-2 infection from February 28th 2020 to January 31st 2021 were enrolled. For each Case, 2 patients without dementia observed in the same period study, pair matched for gender, age (±5 years), PaO2/FiO2 (P/F) ratio at admission (<200, or >200), number of comorbidities (±1; excluding dementia) were chosen (Control group).RESULTS:
The majority of patients were males (60.9% of Cases and Controls) and very elderly [median age 82 years (IQR 75.5-85) in the Cases and 80 (IQR 75.5-83.75) in the Controls]. The prevalence of co-pathologies was very high all the Cases and 43 (93.5%) Controls showed a Charlson comorbidity index of at least 2. During hospitalization the patients in the Case group less frequently had a moderate disease of COVID-19 (35 vs. 67.4%, p = 0.02), more frequently a severe disease (48 vs. 22%, p = 0.03) and more frequently died (48 vs. 22%, p = 0.03). Moreover, during coronavirus disease 2019 (COVID-19), 14 (60.8%) patients in the Case group and 1 (2.1%; p < 0.000) in the Control group showed signs and symptoms of delirium.CONCLUSION:
Patients with dementia are vulnerable and have an increased risk of a severe disease and death when infected with COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Front Aging Neurosci
Year:
2021
Document Type:
Article
Affiliation country:
Fnagi.2021.698184
Similar
MEDLINE
...
LILACS
LIS