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Emerging Advances of Nanotechnology in Drug and Vaccine Delivery against Viral Associated Respiratory Infectious Diseases (VARID).
Seyfoori, Amir; Shokrollahi Barough, Mahdieh; Mokarram, Pooneh; Ahmadi, Mazaher; Mehrbod, Parvaneh; Sheidary, Alireza; Madrakian, Tayyebeh; Kiumarsi, Mohammad; Walsh, Tavia; McAlinden, Kielan D; Ghosh, Chandra C; Sharma, Pawan; Zeki, Amir A; Ghavami, Saeid; Akbari, Mohsen.
  • Seyfoori A; Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
  • Shokrollahi Barough M; Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
  • Mokarram P; Department of Immunology, Iran University of Medical Sciences, Tehran 1449614535, Iran.
  • Ahmadi M; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
  • Mehrbod P; Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran.
  • Sheidary A; Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran.
  • Madrakian T; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran.
  • Kiumarsi M; Influenza and Respiratory Viruses Department, Pasteur Institute of IRAN, Tehran 1316943551, Iran.
  • Walsh T; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
  • McAlinden KD; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran.
  • Ghosh CC; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
  • Sharma P; Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
  • Zeki AA; Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
  • Ghavami S; Department of Laboratory Medicine, School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia.
  • Akbari M; Roger Williams Medical Center, Immuno-Oncology Institute (Ix2), Providence, RI 02908, USA.
Int J Mol Sci ; 22(13)2021 Jun 28.
Article in English | MEDLINE | ID: covidwho-1288899
ABSTRACT
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting the respiratory system. For the past 100 years, viral associated respiratory epidemics have been the most common cause of infectious disease worldwide. Due to several drawbacks of the current anti-viral treatments, such as drug resistance generation and non-targeting of viral proteins, the development of novel nanotherapeutic or nano-vaccine strategies can be considered essential. Due to their specific physical and biological properties, nanoparticles hold promising opportunities for both anti-viral treatments and vaccines against viral infections. Besides the specific physiological properties of the respiratory system, there is a significant demand for utilizing nano-designs in the production of vaccines or antiviral agents for airway-localized administration. SARS-CoV-2, as an immediate example of respiratory viruses, is an enveloped, positive-sense, single-stranded RNA virus belonging to the coronaviridae family. COVID-19 can lead to acute respiratory distress syndrome, similarly to other members of the coronaviridae. Hence, reviewing the current and past emerging nanotechnology-based medications on similar respiratory viral diseases can identify pathways towards generating novel SARS-CoV-2 nanotherapeutics and/or nano-vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Respiratory Tract Infections / Virus Diseases / Drug Carriers / Viral Vaccines / Nanomedicine Subject: Antiviral Agents / Respiratory Tract Infections / Virus Diseases / Drug Carriers / Viral Vaccines / Nanomedicine Type of study: Risk factors Language: English Clinical aspect: Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Respiratory Tract Infections / Virus Diseases / Drug Carriers / Viral Vaccines / Nanomedicine Subject: Antiviral Agents / Respiratory Tract Infections / Virus Diseases / Drug Carriers / Viral Vaccines / Nanomedicine Type of study: Risk factors Language: English Clinical aspect: Therapy Year: 2021
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