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A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov.
Abiri, Rambod; Abdul-Hamid, Hazandy; Sytar, Oksana; Abiri, Ramin; Bezerra de Almeida, Eduardo; Sharma, Surender K; Bulgakov, Victor P; Arroo, Randolph R J; Malik, Sonia.
  • Abiri R; Department of Forestry Science and Biodiversity, Faculty of Forestry and Environment, Universiti Putra Malaysia, Serdang 43400, Malaysia.
  • Abdul-Hamid H; Department of Forestry Science and Biodiversity, Faculty of Forestry and Environment, Universiti Putra Malaysia, Serdang 43400, Malaysia.
  • Sytar O; Laboratory of Bioresource Management, Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, Serdang 43400, Malaysia.
  • Abiri R; Educational and Scientific Center "Institute of Biology and Medicine", Department of Plant Biology, Taras Shevchenko National University of Kyiv, Volodymyrska 60, 01033 Kyiv, Ukraine.
  • Bezerra de Almeida E; Department of Plant Physiology, Slovak University of Agriculture Nitra, A. Hlinku 2, 94976 Nitra, Slovakia.
  • Sharma SK; Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6718773654, Iran.
  • Bulgakov VP; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6718773654, Iran.
  • Arroo RRJ; Biological and Health Sciences Centre, Laboratory of Botanical Studies, Department of Biology, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
  • Malik S; Department of Physics, Central University of Punjab, Bathinda 151401, India.
Molecules ; 26(13)2021 Jun 24.
Article in English | MEDLINE | ID: covidwho-1288959
ABSTRACT
The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds. Since ancient times, herbal medicines have been extensively applied in the treatment and prevention of various infectious diseases in different traditional systems. The purpose of this review is to highlight the potential antiviral activity of plant compounds as effective and reliable agents against viral infections, especially by viruses from the coronavirus group. Various antiviral mechanisms shown by crude plant extracts and plant-derived bioactive compounds are discussed. The understanding of the action mechanisms of complex plant extract and isolated plant-derived compounds will help pave the way towards the combat of this life-threatening disease. Further, molecular docking studies, in silico analyses of extracted compounds, and future prospects are included. The in vitro production of antiviral chemical compounds from plants using molecular pharming is also considered. Notably, hairy root cultures represent a promising and sustainable way to obtain a range of biologically active compounds that may be applied in the development of novel antiviral agents.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plants, Medicinal / Plant Extracts / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Traditional medicine Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26133868

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plants, Medicinal / Plant Extracts / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Traditional medicine Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26133868