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Case Study of Two Post Vaccination SARS-CoV-2 Infections with P1 Variants in CoronaVac Vaccinees in Brazil.
Estofolete, Cassia F; Banho, Cecilia A; Campos, Guilherme R F; Marques, Beatriz de C; Sacchetto, Livia; Ullmann, Leila S; Possebon, Fabio S; Machado, Luana F; Syrio, Juliana D; Araújo Junior, João P; Bittar, Cintia; Rahal, Paula; Lobo, Suzana M A; Ferreira, Helena Lage; Vasilakis, Nikos; Nogueira, Mauricio L.
  • Estofolete CF; Laboratório de Pesquisas em Virologia (LPV), Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Banho CA; Hospital de Base, São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Campos GRF; Laboratório de Pesquisas em Virologia (LPV), Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Marques BC; Laboratório de Pesquisas em Virologia (LPV), Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Sacchetto L; Laboratório de Pesquisas em Virologia (LPV), Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Ullmann LS; Laboratório de Pesquisas em Virologia (LPV), Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Possebon FS; Biotecnology Institute, São Paulo State University (UNESP), Botucatu, São Paulo 18607-440, Brazil.
  • Machado LF; Biotecnology Institute, São Paulo State University (UNESP), Botucatu, São Paulo 18607-440, Brazil.
  • Syrio JD; Hospital de Base, São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Araújo Junior JP; Hospital de Base, São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Bittar C; Biotecnology Institute, São Paulo State University (UNESP), Botucatu, São Paulo 18607-440, Brazil.
  • Rahal P; Intitute of Biosciences, Languages and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo 15054-000, Brazil.
  • Lobo SMA; Intitute of Biosciences, Languages and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo 15054-000, Brazil.
  • Ferreira HL; Hospital de Base, São José do Rio Preto, São Paulo 15090-000, Brazil.
  • Vasilakis N; Department of Veterinary Medicine FZEA-USP, University of São Paulo (USP), Pirassununga, São Paulo 13635-900, Brazil.
  • Nogueira ML; Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Viruses ; 13(7)2021 06 26.
Article in English | MEDLINE | ID: covidwho-1289023
ABSTRACT
The rapid development of efficacious and safe vaccines against coronavirus disease 2019 (COVID-19) has been instrumental in mitigating the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the emergence of SARS-CoV-2 variants raised concerns on the efficacy of these vaccines. Herein, we report two cases of breakthrough infections with the P1 variant in patients vaccinated with CoronaVac, which is one of the two vaccines authorized for emergency use in the Brazilian immunization program. Our observations suggest that the vaccine reduced the severity of the disease and highlight the potential risk of illness following vaccination and subsequent infection with the P1 variant as well as for continued efforts to prevent and diagnose infection in vaccinated persons.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2021 Document Type: Article Affiliation country: V13071237

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Year: 2021 Document Type: Article Affiliation country: V13071237