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From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion.
Atkins, John F; O'Connor, Kate M; Bhatt, Pramod R; Loughran, Gary.
  • Atkins JF; Schools of Biochemistry and Microbiology, University College Cork, T12 XF62 Cork, Ireland.
  • O'Connor KM; Schools of Biochemistry and Microbiology, University College Cork, T12 XF62 Cork, Ireland.
  • Bhatt PR; Schools of Biochemistry and Microbiology, University College Cork, T12 XF62 Cork, Ireland.
  • Loughran G; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland.
Viruses ; 13(7)2021 06 27.
Article in English | MEDLINE | ID: covidwho-1289026
ABSTRACT
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine. This recoding can effectively increase viral coding capacity and generate a set ratio of products with the same N-terminal domain(s) but different C-terminal domains. Recoding can also be regulatory or generate a product with the non-universal 21st directly encoded amino acid. Selection for translation speed in the expression of many viruses at the expense of fidelity creates host immune defensive opportunities. In contrast to host opportunism, certain viruses, including some persistent viruses, utilize recoding or adventitious frameshifting as part of their strategy to evade an immune response or specific drugs. Several instances of recoding in small intensively studied viruses escaped detection for many years and their identification resolved dilemmas. The fundamental importance of ribosome ratcheting is consistent with the initial strong view of invariant triplet decoding which however did not foresee the possibility of transitory anticodoncodon dissociation. Deep level dynamics and structural understanding of recoding is underway, and a high level structure relevant to the frameshifting required for expression of the SARS CoV-2 genome has just been determined.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Histocompatibility Antigens Class I / DNA Viruses / Immune Evasion Language: English Year: 2021 Document Type: Article Affiliation country: V13071251

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Histocompatibility Antigens Class I / DNA Viruses / Immune Evasion Language: English Year: 2021 Document Type: Article Affiliation country: V13071251