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Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19.
de Nooijer, Aline H; Grondman, Inge; Lambden, Simon; Kooistra, Emma J; Janssen, Nico A F; Kox, Matthijs; Pickkers, Peter; Joosten, Leo A B; van de Veerdonk, Frank L; Derive, Marc; Gibot, Sebastien; Netea, Mihai G.
  • de Nooijer AH; Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Grondman I; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Lambden S; Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Kooistra EJ; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Janssen NAF; Department of Medicine, University of Cambridge, Cambridge, CB20 QQ, UK.
  • Kox M; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Pickkers P; Department of Intensive Care Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Joosten LAB; Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • van de Veerdonk FL; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Derive M; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Gibot S; Department of Intensive Care Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
  • Netea MG; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Biosci Rep ; 41(7)2021 07 30.
Article in English | MEDLINE | ID: covidwho-1290282
ABSTRACT
Patients with sepsis display increased concentrations of sTREM-1 (soluble Triggering Receptor Expressed on Myeloid cells 1), and a phase II clinical trial focusing on TREM-1 modulation is ongoing. We investigated whether sTREM-1 circulating concentrations are associated with the outcome of patients with coronavirus disease 2019 (COVID-19) to assess the role of this pathway in COVID-19. This observational study was performed in two independent cohorts of patients with COVID-19. Plasma concentrations of sTREM-1 were assessed after ICU admission (pilot cohort) or after COVID-19 diagnosis (validation cohort). Routine laboratory and clinical parameters were collected from electronic patient files. Results showed sTREM-1 plasma concentrations were significantly elevated in patients with COVID-19 (161 [129-196] pg/ml) compared to healthy controls (104 [75-124] pg/ml; P<0.001). Patients with severe COVID-19 needing ICU admission displayed even higher sTREM-1 concentrations compared to less severely ill COVID-19 patients receiving clinical ward-based care (235 [176-319] pg/ml and 195 [139-283] pg/ml, respectively, P = 0.017). In addition, higher sTREM-1 plasma concentrations were observed in patients who did not survive the infection (326 [207-445] pg/ml) compared to survivors (199 [142-278] pg/ml, P<0.001). Survival analyses indicated that patients with higher sTREM-1 concentrations are at higher risk for death (hazard ratio = 3.3, 95%CI 1.4-7.8). In conclusion, plasma sTREM-1 concentrations are elevated in patients with COVID-19, relate to disease severity, and discriminate between survivors and non-survivors. This suggests that the TREM-1 pathway is involved in the inflammatory reaction and the disease course of COVID-19, and therefore may be considered as a therapeutic target in severely ill patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Triggering Receptor Expressed on Myeloid Cells-1 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: BSR20210940

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Triggering Receptor Expressed on Myeloid Cells-1 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: BSR20210940