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Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro.
Du, Ruikun; Cooper, Laura; Chen, Zinuo; Lee, Hyun; Rong, Lijun; Cui, Qinghua.
  • Du R; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Qingdao Academy of Chinese Medicinal Sciences, Shandong University of Traditional Chinese Medicine, Qingdao,
  • Cooper L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Chen Z; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
  • Lee H; Department of Pharmaceutical Sciences, Center for Biomolecular Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, 60607, USA.
  • Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address: Lijun@uic.edu.
  • Cui Q; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Qingdao Academy of Chinese Medicinal Sciences, Shandong University of Traditional Chinese Medicine, Qingdao,
Antiviral Res ; 190: 105075, 2021 06.
Article in English | MEDLINE | ID: covidwho-1290345
ABSTRACT
The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease. Here we examined the inhibitory abilities of two broad-spectrum antiviral natural products chebulagic acid (CHLA) and punicalagin (PUG) against SARS-CoV-2 viral replication. Both CHLA and PUG reduced virus-induced plaque formation in Vero-E6 monolayer at noncytotoxic concentrations, by targeting the enzymatic activity of viral 3-chymotrypsin-like cysteine protease (3CLpro) as allosteric regulators. Our study demonstrates the potential use of CHLA and PUG as novel COVID-19 therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzopyrans / Hydrolyzable Tannins / Coronavirus 3C Proteases / SARS-CoV-2 / Glucosides Limits: Animals Language: English Journal: Antiviral Res Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Benzopyrans / Hydrolyzable Tannins / Coronavirus 3C Proteases / SARS-CoV-2 / Glucosides Limits: Animals Language: English Journal: Antiviral Res Year: 2021 Document Type: Article