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Characteristics Associated with Olfactory and Taste Disorders in COVID-19.
Galmiche, Simon; Bruel, Timothée; Madec, Yoann; Tondeur, Laura; Grzelak, Ludivine; Staropoli, Isabelle; Cailleau, Isabelle; Ungeheuer, Marie-Noëlle; Renaudat, Charlotte; Fernandes Pellerin, Sandrine; Hoen, Bruno; Schwartz, Olivier; Fontanet, Arnaud.
  • Galmiche S; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France, simon-galmiche@hotmail.fr.
  • Bruel T; Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
  • Madec Y; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Tondeur L; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Grzelak L; Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
  • Staropoli I; UMR 3569, Centre National de la Recherche Scientifique (CNRS), Paris, France.
  • Cailleau I; Université de Paris, Sorbonne Paris Cité, Paris, France.
  • Ungeheuer MN; Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
  • Renaudat C; Direction de la recherche médicale, Institut Pasteur, Paris, France.
  • Fernandes Pellerin S; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Sciences, Institut Pasteur, Paris, France.
  • Hoen B; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Sciences, Institut Pasteur, Paris, France.
  • Schwartz O; Center for Translational Sciences, Institut Pasteur, Paris, France.
  • Fontanet A; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
Neuroepidemiology ; 55(5): 381-386, 2021.
Article in English | MEDLINE | ID: covidwho-1290486
ABSTRACT

INTRODUCTION:

Olfactory and taste disorders (OTDs) have been reported in COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the mechanisms of which remain unclear. We conducted a detailed analysis of OTDs as part of 2 seroepidemiological investigations of COVID-19 outbreaks.

METHODS:

Two retrospective cohort studies were conducted in a high school and primary schools of Northern France following a COVID-19 epidemic in February-March 2020. Students, their relatives, and school staff were included. Anti-SARS-CoV-2 antibodies were identified using a flow-cytometry-based assay detecting anti-S IgG.

RESULTS:

Among 2,004 participants (median [IQR] age 31 [11-43] years), 303 (15.2%) tested positive for SARS-CoV-2 antibodies. OTDs were present in 91 (30.0%) and 92 (30.3%) of them, respectively, and had 85.1 and 78.0% positive predictive values for SARS-CoV-2 infection, respectively. In seropositive participants, OTDs were independently associated with an age above 18 years, female gender, fatigue, and headache.

CONCLUSION:

This study confirms the higher frequency of OTDs in females than males and adults than children. Their high predictive value for the diagnosis of COVID-19 suggests that they should be systematically searched for in patients with respiratory symptoms, fever, or headache. The association of OTDs with headache, not previously reported, suggests that they share a common mechanism, which deserves further investigation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Taste Disorders / COVID-19 / Olfaction Disorders Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Child / Humans / Young adult Language: English Journal: Neuroepidemiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Taste Disorders / COVID-19 / Olfaction Disorders Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Child / Humans / Young adult Language: English Journal: Neuroepidemiology Year: 2021 Document Type: Article