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An all-out assault on SARS-CoV-2 replication.
Hay, Ronald T.
  • Hay RT; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Biochem J ; 478(13): 2399-2403, 2021 07 16.
Article in English | MEDLINE | ID: covidwho-1290629
ABSTRACT
The coronavirus pandemic has had a huge impact on public health with over 165 million people infected, 3.4 million deaths and a hugely deleterious effect on most economies. While vaccination effectively protects against the disease it is likely that viruses will evolve that can replicate in hosts immunised with the present vaccines. Thus, there is a great unmet need for effective antivirals that can block the development of serious disease in infected patients. The seven papers published in this issue of the Biochemical Journal address this need by expressing and purifying components required for viral replication, developing biochemical assays for these components and using the assays to screen a library of pre-existing pharmaceuticals for drugs that inhibited the target in vitro and inhibited viral replication in cell culture. The candidate drugs obtained are potential antivirals that may protect against SARS-CoV-2 infection. While not all the antiviral candidates will make it through to the clinic, they will be useful tool compounds and can act as the starting point for further drug discovery programmes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Virus Replication / Drug Evaluation, Preclinical / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Biochem J Year: 2021 Document Type: Article Affiliation country: Bcj20210256

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Virus Replication / Drug Evaluation, Preclinical / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Traditional medicine / Vaccines Limits: Humans Language: English Journal: Biochem J Year: 2021 Document Type: Article Affiliation country: Bcj20210256