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Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020-March 2021.
Kompaniyets, Lyudmyla; Pennington, Audrey F; Goodman, Alyson B; Rosenblum, Hannah G; Belay, Brook; Ko, Jean Y; Chevinsky, Jennifer R; Schieber, Lyna Z; Summers, April D; Lavery, Amy M; Preston, Leigh Ellyn; Danielson, Melissa L; Cui, Zhaohui; Namulanda, Gonza; Yusuf, Hussain; Mac Kenzie, William R; Wong, Karen K; Baggs, James; Boehmer, Tegan K; Gundlapalli, Adi V.
  • Kompaniyets L; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Pennington AF; Centers for Disease Control and Prevention, 4770 Buford Hwy, MS S107-5, Atlanta GA 30341. Email: LKompaniyets@cdc.gov.
  • Goodman AB; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Rosenblum HG; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Belay B; US Public Health Service Commissioned Corps, Rockville, Maryland.
  • Ko JY; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Chevinsky JR; Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Schieber LZ; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Summers AD; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Lavery AM; US Public Health Service Commissioned Corps, Rockville, Maryland.
  • Preston LE; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Danielson ML; Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Cui Z; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Namulanda G; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Yusuf H; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Mac Kenzie WR; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Wong KK; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Baggs J; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Boehmer TK; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Gundlapalli AV; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
Prev Chronic Dis ; 18: E66, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1290851
ABSTRACT

INTRODUCTION:

Severe COVID-19 illness in adults has been linked to underlying medical conditions. This study identified frequent underlying conditions and their attributable risk of severe COVID-19 illness.

METHODS:

We used data from more than 800 US hospitals in the Premier Healthcare Database Special COVID-19 Release (PHD-SR) to describe hospitalized patients aged 18 years or older with COVID-19 from March 2020 through March 2021. We used multivariable generalized linear models to estimate adjusted risk of intensive care unit admission, invasive mechanical ventilation, and death associated with frequent conditions and total number of conditions.

RESULTS:

Among 4,899,447 hospitalized adults in PHD-SR, 540,667 (11.0%) were patients with COVID-19, of whom 94.9% had at least 1 underlying medical condition. Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. The strongest risk factors for death were obesity (adjusted risk ratio [aRR] = 1.30; 95% CI, 1.27-1.33), anxiety and fear-related disorders (aRR = 1.28; 95% CI, 1.25-1.31), and diabetes with complication (aRR = 1.26; 95% CI, 1.24-1.28), as well as the total number of conditions, with aRRs of death ranging from 1.53 (95% CI, 1.41-1.67) for patients with 1 condition to 3.82 (95% CI, 3.45-4.23) for patients with more than 10 conditions (compared with patients with no conditions).

CONCLUSION:

Certain underlying conditions and the number of conditions were associated with severe COVID-19 illness. Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. Careful evaluation and management of underlying conditions among patients with COVID-19 can help stratify risk for severe illness.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Phobic Disorders / Diabetes Complications / Noncommunicable Diseases / Multimorbidity / COVID-19 / Hospitalization / Obesity Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: North America Language: English Journal: Prev Chronic Dis Journal subject: Public Health Year: 2021 Document Type: Article Affiliation country: Pcd18.210123

Full text: Available Collection: International databases Database: MEDLINE Main subject: Phobic Disorders / Diabetes Complications / Noncommunicable Diseases / Multimorbidity / COVID-19 / Hospitalization / Obesity Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: North America Language: English Journal: Prev Chronic Dis Journal subject: Public Health Year: 2021 Document Type: Article Affiliation country: Pcd18.210123