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Prevalence of SARS-CoV-2 antibodies among workers of the public higher education institutions of Porto, Portugal: a cross-sectional study.
Meireles, Paula; Amaro, Joana; Pinto da Costa, Joana; Lopes, Mariana Mendes; Varandas, Tatiana; Norton, Pedro; Guimarães, João Tiago; Severo, Milton; Barros, Henrique.
  • Meireles P; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal paula.meireles@ispup.up.pt.
  • Amaro J; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
  • Pinto da Costa J; Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
  • Lopes MM; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
  • Varandas T; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
  • Norton P; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
  • Guimarães JT; EPI Unit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
  • Severo M; Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
  • Barros H; Serviço de Saúde Ocupacional, Centro Hospitalar Universitário de São João, Porto, Portugal.
Occup Environ Med ; 78(9): 648-653, 2021 09.
Article in English | MEDLINE | ID: covidwho-1291143
ABSTRACT

OBJECTIVES:

To assess the prevalence of SARS-CoV-2-specific IgM and IgG antibodies among workers of the three public higher education institutions of Porto, Portugal, up to July 2020.

METHODS:

A rapid point-of-care test for specific IgM and IgG antibodies of SARS-CoV-2 was offered to all workers (SD Biosensor STANDARD Q COVID-19 IgM/IgG Duo and STANDARD Q COVID-19 IgM/IgG Combo). Testing was performed and a questionnaire was completed by 4592 workers on a voluntary basis from 21 May to 31 July 2020. We computed the apparent IgM, IgG, and combined IgM or IgG prevalence, along with the true prevalence and 95% credible intervals (95% CrI) using Bayesian inference.

RESULTS:

We found an apparent prevalence of 3.1% for IgM, 1.0% for IgG and 3.9% for either. The estimated true prevalence was 2.0% (95% CrI 0.1% to 4.3%) for IgM, 0.6% (95% CrI 0.0% to 1.3%) for IgG, and 2.5% (95% CrI 0.1% to 5.3%) for IgM or IgG. A SARS-CoV-2 molecular diagnosis was reported by 21 (0.5%) workers; and of these, 90.5% had a reactive IgG result. Seroprevalence was higher among those reporting contacts with confirmed cases, having been quarantined, having a previous molecular negative test or having had symptoms.

CONCLUSIONS:

The seroprevalence among workers from the three public higher education institutions of Porto after the first wave of the SARS-CoV-2 infection was similar to national estimates for the same age working population. However, the estimated true seroprevalence was approximately five times higher than the reported SARS-CoV-2 infection based on a molecular test.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schools / Workplace / SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Occup Environ Med Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article Affiliation country: Oemed-2021-107519

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schools / Workplace / SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Occup Environ Med Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article Affiliation country: Oemed-2021-107519