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Cardiovascular magnetic resonance imaging in children after recovery from symptomatic COVID-19 or MIS-C: a prospective study.
Webster, Gregory; Patel, Ami B; Carr, Michael R; Rigsby, Cynthia K; Rychlik, Karen; Rowley, Anne H; Robinson, Joshua D.
  • Webster G; Division of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Box 21, Chicago, IL, 60611, USA. rgwebster@luriechildrens.org.
  • Patel AB; Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
  • Carr MR; Division of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Box 21, Chicago, IL, 60611, USA.
  • Rigsby CK; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Rychlik K; Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
  • Rowley AH; Biostatistics Research Core, Stanley Manne Children's Research Institute, Chicago, IL, USA.
  • Robinson JD; Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
J Cardiovasc Magn Reson ; 23(1): 86, 2021 07 01.
Article in English | MEDLINE | ID: covidwho-1292072
ABSTRACT

BACKGROUND:

Cardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1-3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery.

METHODS:

We performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic.

RESULTS:

CMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children.

CONCLUSIONS:

Children prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Imaging / Systemic Inflammatory Response Syndrome / COVID-19 / Heart Type of study: Diagnostic study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: J Cardiovasc Magn Reson Journal subject: Vascular Diseases / Cardiology / Diagnostic Imaging Year: 2021 Document Type: Article Affiliation country: S12968-021-00786-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Imaging / Systemic Inflammatory Response Syndrome / COVID-19 / Heart Type of study: Diagnostic study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: J Cardiovasc Magn Reson Journal subject: Vascular Diseases / Cardiology / Diagnostic Imaging Year: 2021 Document Type: Article Affiliation country: S12968-021-00786-5