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Studying Evolutionary Adaptation of MERS-CoV.
Letko, Michael; Munster, Vincent.
  • Letko M; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, USA. michael.letko@nih.gov.
  • Munster V; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, USA.
Methods Mol Biol ; 2099: 3-8, 2020.
Article in English | MEDLINE | ID: covidwho-1292543
ABSTRACT
Forced viral adaptation is a powerful technique employed to study the ways viruses may overcome various selective pressures that reduce viral replication. Here, we describe methods for in vitro serial passaging of Middle East respiratory syndrome coronavirus (MERS-CoV) to select for mutations which increase replication on semi-permissive cell lines as described in Letko et al., Cell Rep 24, 1730-1737, 2018.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Adaptation, Physiological / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Limits: Animals / Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: 978-1-0716-0211-9_1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Adaptation, Physiological / Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Limits: Animals / Humans Language: English Journal: Methods Mol Biol Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: 978-1-0716-0211-9_1