Liposome composition in drug delivery design, synthesis, characterization, and clinical application.

Large, Danielle E; Abdelmessih, Rudolf G; Fink, Elizabeth A; Auguste, Debra T

Large, Danielle E; Abdelmessih, Rudolf G; Fink, Elizabeth A; Auguste, Debra T.

Large DE; Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
Abdelmessih RG; Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
Fink EA; Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
Auguste DT; Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. Electronic address: d.auguste@northeastern.edu.

Adv Drug Deliv Rev ; 176: 113851, 2021 09.

Article in English | MEDLINE | ID: covidwho-1292566

ABSTRACT

ABSTRACT

Liposomal drug delivery represents a highly adaptable therapeutic platform for treating a wide range of diseases. Natural and synthetic lipids, as well as surfactants, are commonly utilized in the synthesis of liposomal drug delivery vehicles. The molecular diversity in the composition of liposomes enables drug delivery with unique physiological functions, such as pH response, prolonged blood circulation, and reduced systemic toxicity. Herein, we discuss the impact of composition on liposome synthesis, function, and clinical utility.

Subject(s)

Drug Delivery Systems; Drug Design; Lipids/chemistry; Animals; Humans; Hydrogen-Ion Concentration; Liposomes; Pharmaceutical Preparations/administration & dosage; Pharmaceutical Preparations/chemistry; Surface-Active Agents/chemistry

Keywords

Liposomal drug delivery; Liposome functionality; Liposome synthesis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Design / Drug Delivery Systems / Lipids Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: J.addr.2021.113851

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