The role of the envelope protein in the stability of a coronavirus model membrane against an ethanolic disinfectant.
J Chem Phys
; 154(24): 245101, 2021 Jun 28.
Article
in English
| MEDLINE | ID: covidwho-1293030
ABSTRACT
Ethanol is highly effective against various enveloped viruses and can disable the virus by disintegrating the protective envelope surrounding it. The interactions between the coronavirus envelope (E) protein and its membrane environment play key roles in the stability and function of the viral envelope. By using molecular dynamics simulation, we explore the underlying mechanism of ethanol-induced disruption of a model coronavirus membrane and, in detail, interactions of the E-protein and lipids. We model the membrane bilayer as N-palmitoyl-sphingomyelin and 1-palmitoyl-2-oleoylphosphatidylcholine lipids and the coronavirus E-protein. The study reveals that ethanol causes an increase in the lateral area of the bilayer along with thinning of the bilayer membrane and orientational disordering of lipid tails. Ethanol resides at the head-tail region of the membrane and enhances bilayer permeability. We found an envelope-protein-mediated increase in the ordering of lipid tails. Our simulations also provide important insights into the orientation of the envelope protein in a model membrane environment. At â¼25 mol. % of ethanol in the surrounding ethanol-water phase, we observe disintegration of the lipid bilayer and dislocation of the E-protein from the membrane environment.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cell Membrane
/
Viral Envelope Proteins
/
Coronavirus
/
Disinfectants
/
Ethanol
Language:
English
Journal:
J Chem Phys
Year:
2021
Document Type:
Article
Affiliation country:
5.0055331
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